Home DNA Damage/DNA Repair SMN modulator Risdiplam For research use only.

Risdiplam

Synonyms: RG7916, RO7034067

Risdiplam is an orally administered SMN2 pre-mRNA splicing modifier that distributes into the central nervous system (CNS) and peripheral tissues.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!

Risdiplam Chemical Structure

Risdiplam Chemical Structure

CAS: 1825352-65-5

Selleck's Risdiplam has been cited by 1 publication

Purity & Quality Control

Batch: S692501 DMSO] Insoluble] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.58%
99.58

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Biological Activity

Description Risdiplam is an orally administered SMN2 pre-mRNA splicing modifier that distributes into the central nervous system (CNS) and peripheral tissues.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
Targets
SMN2 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05861999 Not yet recruiting Muscular Atrophy Spinal Hoffmann-La Roche March 12 2024 Phase 4
NCT05861986 Not yet recruiting Muscular Atrophy Spinal Hoffmann-La Roche February 7 2024 Phase 4
NCT05808764 Not yet recruiting Muscular Atrophy Spinal Hoffmann-La Roche January 15 2024 Phase 2
NCT05769465 Recruiting Spinal Muscular Atrophy Fondazione Policlinico Universitario Agostino Gemelli IRCCS April 1 2023 --
NCT05115110 Recruiting Spinal Muscular Atrophy (SMA) Hoffmann-La Roche June 2 2022 Phase 2|Phase 3
NCT04718181 Completed Muscular Atrophy Spinal Hoffmann-La Roche February 1 2021 Phase 1

Chemical lnformation & Solubility

Molecular Weight 401.46 Formula

C22H23N7O
CAS No. 1825352-65-5 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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