Home Neuronal Signaling AChR inhibitor Rivastigmine For research use only.

Rivastigmine

Synonyms: SDZ-ENA 713, Exelon

Rivastigmine (SDZ-ENA 713, Exelon) is a cholinesterase inhibitor with IC50 of 5.5 μM. It inhibits acetylcholinesterase (IC50 = 4.15 µM) and butyrylcholinesterase (IC50 = 37 nM).

Rivastigmine Chemical Structure

Rivastigmine Chemical Structure

CAS: 123441-03-2

Selleck's Rivastigmine has been cited by 1 publication

Purity & Quality Control

Batch: S468701 Purity: 99.98%
99.98

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Biological Activity

Description Rivastigmine (SDZ-ENA 713, Exelon) is a cholinesterase inhibitor with IC50 of 5.5 μM. It inhibits acetylcholinesterase (IC50 = 4.15 µM) and butyrylcholinesterase (IC50 = 37 nM).
Targets
cholinesterase [1]
In Vivo
In vivo Preclinical biochemical studies indicates that rivastigmine has central nervous system selectivity over peripheral inhibition. It ameliorates memory impairment in rats with forebrain lesions. The drug is rapidly absorbed orally, with a bioavailability of 0.355 and low protein binding (40%). Its elimination halflife is less than 2 hours, and it is converted to an inactive metabolite at the site of action, bypassing hepatic metabolic pathways. Its disposition essentially is unaltered in patients with renal or hepatic impairment. It also has dosedependent effects on AChE inhibition[1].
Animal Research Animal Models Male Wistar albino rats
Dosages 0.5, 1, 1.5 and 2.5 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05768126 Recruiting Depressive Disorder UMC Utrecht|ZonMw: The Netherlands Organisation for Health Research and Development|St. Antonius Hospital|Tergooi Hospital September 29 2021 Phase 4
NCT01585272 Completed Alzheimer''s Dementia Novartis Pharmaceuticals|Novartis August 2012 Phase 4
NCT01073319 Completed Methamphetamine Dependence|Substance Abuse|Methamphetamine Abuse Baylor College of Medicine|National Institute on Drug Abuse (NIDA) July 2009 Phase 1
NCT01312363 Completed Alzheimer''s Disease Seoul National University Hospital|Seoul National University Bundang Hospital|Seoul St. Mary''s Hospital|Korea University|Bobath Memorial Hospital|Chung-Ang University Hosptial Chung-Ang University College of Medicine|Hanyang University|Kwandong University Myongji Hospital|Inha University Hospital|SungAe General Hospital|Ewha Womans University|Inje University|Hanyang University Seoul Hospital|Kyunghee University Medical Center|Hallym University Medical Center|Pusan National University Hospital|Konyang University Hospital|Wonkwang University Sanbon Medical Center|Yong-in Hyoja Geriatric Hospital|Jeju National University|Dong-A University Hospital June 2009 --
NCT00624663 Completed Rivastigmine Toxicity Tel-Aviv Sourasky Medical Center|Medical Corps Israel Defense Force January 2009 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 250.34 Formula

C14H22N2O2
CAS No. 123441-03-2 SDF Download Rivastigmine SDF
Density 1.038 g/mL
Smiles CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C
Storage (From the date of receipt) 2 years -80°C liquid

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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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