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Roxatidine Acetate HCl

Name: Roxatidine Acetate HCl
Brand: Selleck Chemicals
SKU: S1880

Synonyms: HOE 760

Catalog No.S1880 Purity: 99.48%

Roxatidine Acetate HCl(HOE 760) is a specific and competitive histamin H2-receptor antagonist, with IC50 of 3.2 μM, inhibits gastric acid secretion and ulcer formation.

Roxatidine Acetate HCl Chemical Structure

CAS: 93793-83-0

Purity & Quality Control

Batch: S188001 DMSO] 77 mg/mL] false] Water] 77 mg/mL] false] Ethanol] 12 mg/mL] false Purity: 99.48%

99.48

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Biological Activity

Description

Roxatidine Acetate HCl(HOE 760) is a specific and competitive histamin H2-receptor antagonist, with IC50 of 3.2 μM, inhibits gastric acid secretion and ulcer formation.

Targets

Histamine H2 receptor ^[1]

3.2 μM

Chemical lnformation & Solubility

Molecular Weight	384.9	Formula	C₁₉H₂₈N₂O₄.HCl
CAS No.	93793-83-0	SDF	Download Roxatidine Acetate HCl SDF
Smiles	CC(=O)OCC(=O)NCCCOC1=CC=CC(=C1)CN2CCCCC2.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 77 mg/mL ( (200.05 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 77 mg/mL

Ethanol : 12 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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