Home Microbiology Reverse Transcriptase inhibitor Entecavir For research use only.

Entecavir

Synonyms: BMS200475,SQ34676

Entecavir(BMS200475,SQ34676), a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).

Entecavir Chemical Structure

Entecavir Chemical Structure

CAS: 142217-69-4

Selleck's Entecavir has been cited by 13 publications

Purity & Quality Control

Batch: Purity: 99.73%
99.73

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Biological Activity

Description Entecavir(BMS200475,SQ34676), a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV).
In vitro
In vitro

For treatment of hepatitis B virus, combinations of ETV with each of the other HBV NRTI antivirals, adefovir, tenofovir, and lamivudine at 10 times their respective Cmax levels fails to result in cellular or mitochondrial toxicity, and displays no DNA polymerase gamma inhibition.[1]
Cell Research Cell lines HepG2 cells
Concentrations 0.034 - 3.4 μM
Incubation Time 15 days
Method

HepG2 cells (2.7 × 106) are seeded onto collagen I-coated T75 flasks. Cultures are exposed to compounds for a total of 15 days, reseeding every 5 days to the original cell density. In addition, media and compounds are also replaced 3 days after seeding. This schedule results in replacement of media containing fresh compound on days 1, 3, 5, 8, 10, and 13. Cells and culture supernatants are harvested and assayed on days 5, 10, and 15.
In Vivo
In vivo

Treatment with Entecavir in combination with AIC649, Induces tightly regulated Immunological and virological responses during active and maintenance ereatment in the woodchuck model of chronic hepatitis B.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05874440 Recruiting Chronic Hepatitis b Patients Sohag University April 15 2023 --
NCT04454567 Terminated Chronic Hepatitis B Assembly Biosciences November 11 2020 Phase 2
NCT04157257 Unknown status Chronic Hepatitis b Qilu Pharmaceutical Co. Ltd. July 26 2019 Phase 2
NCT03576066 Completed Chronic Hepatitis B Assembly Biosciences June 11 2018 Phase 2

Chemical lnformation & Solubility

Molecular Weight 277.28 Formula

C12H15N5O3
CAS No. 142217-69-4 SDF --
Smiles C=C1C(CC(C1CO)O)N2C=NC3=C2N=C(NC3=O)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 55 mg/mL ( (198.35 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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