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Sacituzumab-govitecan

Name: Sacituzumab-govitecan
Brand: Selleck Chemicals
SKU: E2841

Synonyms: IMMU-132

Catalog No.E2841 Purity: 98.93%

Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38, showing anticancer activity. Sacituzumab govitecan has a molecular weight of 160KDa. This product is supplied as 10mg/ml PBS solution.This product is discontinued. We recommend the replacement products: D4002.

Sacituzumab-govitecan Chemical Structure

CAS: 1491917-83-9 (ADC)

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Purity & Quality Control

Batch: E284101 Purity: 98.93%

98.93

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Biological Activity

Description	Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38, showing anticancer activity. Sacituzumab govitecan has a molecular weight of 160KDa. This product is supplied as 10mg/ml PBS solution.This product is discontinued. We recommend the replacement products: D4002.

In vitro
In vitro	Sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC) made from a humanized anti-Trop-2 monoclonal antibody (hRS7) conjugated with the active metabolite of irinotecan, SN-38, shows anticancer activity in cancers expressing Trop-2, including gastric and pancreatic cancer.
Cell Research	Cell lines	BxPC-3 cells
	Concentrations	20 µg/ml
	Incubation Time	30 minutes
	Method	Cells were treated with indicated concentration of drug for 30 minutes.

References

[1] Cardillo TM, et al. Bioconjug Chem. 2015 May 20;26(5):919-31.

Chemical lnformation & Solubility

Molecular Weight	160000	Formulation	10mg/mL in PBS
DAR	7.6	Antibody	Sacituzumab
ADC Cytotoxin	SN-38	Formula	C₇₆H₁₀₄N₁₂O₂₄S
CAS No.	1491917-83-9 (ADC)	Storage (From the date of receipt)	1 year -80°C in solvent
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

In vitro
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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

Question 1:
What’s the solvent of this ADC drug? And what‘s its concentration?

Answer:
The solvent is a PBS solution. The concentration is 10mg/ml.

Question 2:
What is the molecular weight of Sacituzumab govitecan (IMMU-132)?

Answer:
Sacituzumab govitecan (IMMU-132) contains on average 7 to 8 molecules of SN-38 per antibody molecule. Sacituzumab govitecan (IMMU-132) has a molecular weight of approximately 160 kilodaltons. The molecular weight of the drug (SN-38) and linker other than the antibody is 1601.8.

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