Home Proteases Neprilysin inhibitor Sacubitril hemicalcium salt For research use only.

Sacubitril hemicalcium salt

Synonyms: AHU-377 hemicalcium salt

Sacubitril (AHU-377) hemicalcium salt, a component of the heart failure medicine LCZ696, is a potent inhibitor of neprilysin (neutral endopeptidase, NEP).

Sacubitril hemicalcium salt Chemical Structure

Sacubitril hemicalcium salt Chemical Structure

CAS: 1369773-39-6

Purity & Quality Control

Batch: Purity: 99.71%
99.71

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Biological Activity

Description Sacubitril (AHU-377) hemicalcium salt, a component of the heart failure medicine LCZ696, is a potent inhibitor of neprilysin (neutral endopeptidase, NEP).
Targets
NEP [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05989503 Recruiting Heart Failure With Reduced Ejection Fraction Universidade do Porto|Faculty of Medicine (FMUP)|Unidade de Investigação e Desenvolvimento Cardiovascular (UnIC)|Rede de Investigação em Saúde (RISE) Laboratório Associado August 4 2023 Phase 4
NCT05870709 Withdrawn Heart Failure Novartis Pharmaceuticals|Novartis May 15 2023 --
NCT05564572 Enrolling by invitation Heart Failure Stanford University September 7 2022 Not Applicable
NCT05194111 Recruiting Heart Failure|Heart Dysfunction Virginia Commonwealth University March 9 2022 Phase 1|Phase 2
NCT05963282 Completed de Novo Heart Failure Novartis Pharmaceuticals|Novartis November 29 2021 --

Chemical lnformation & Solubility

Molecular Weight 861.04 Formula

C48H56CaN2O10
CAS No. 1369773-39-6 SDF --
Smiles [Ca++].CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC([O-])=O.CCOC(=O)C(C)CC(CC3=CC=C(C=C3)C4=CC=CC=C4)NC(=O)CCC([O-])=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 50 mg/mL ( (58.06 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 25 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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