Home Microbiology Reverse Transcriptase inhibitor - Integrase inhibitor - Fungal inhibitor Salicylanilide For research use only.

Salicylanilide

Synonyms: WR10019,2-Hydroxybenzanilide

Salicylanilides (WR10019,2-Hydroxybenzanilide) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.

Salicylanilide Chemical Structure

Salicylanilide Chemical Structure

CAS: 87-17-2

Selleck's Salicylanilide has been cited by 1 publication

Purity & Quality Control

Batch: S418701 DMSO] 43 mg/mL] false] Ethanol] 18 mg/mL] false] Water] Insoluble] false Purity: 99.99%
99.99

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Biological Activity

Description Salicylanilides (WR10019,2-Hydroxybenzanilide) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities.
Targets
reverse transcriptase [1] integrase [1]
In vitro
In vitro

Some salicylanilides and salicylamides could inhibit HIV virus by targeting of HIV-1 integrase or reverse transcriptase. Hepatitis C virus could be potentially afflicted by salicylanilides on the level of two enzymes – NS3 protease and NS5B RNA polymerase. Nitazoxanide is a nitrothiazole derivative of salicylamide useful for the treatment of protozoal and bacterial infections with an extended range of antiviral activity and innovative mechanism of action, especially against hepatitis and influenza viruses or rotaviruses. Nitazoxanide, its metabolite tizoxanide and their derivatives are a very promising stream in the development of new antiviral compounds.[1] Salicylanilides is potential virulence inhibitors attributable to a blockade of the type III secretion pathway. Many salicylanilide ester derivatives have been demonstrated an effective and promising treatment against pathogenic fungi and bacteria (especially against Gram-positive, tuberculous and atypical mycobacterial strains), including strains such as methicillinresistant Staphylococcus aureus and isoniazid-resistant mycobacteria which are resistant to one or more clinically used drugs.[2]

Chemical lnformation & Solubility

Molecular Weight 213.23 Formula

C13H11NO2
CAS No. 87-17-2 SDF Download Salicylanilide SDF
Smiles C1=CC=C(C=C1)NC(=O)C2=CC=CC=C2O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 43 mg/mL ( (201.66 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 18 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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