Home Microbiology HIV Protease inhibitor Saquinavir (Ro 31-8959) For research use only.

Saquinavir (Ro 31-8959)

Synonyms: Ro 31-8959,SAQ

Saquinavir (Ro 31-8959,SAQ) is a potent and selective inhibitor of HIV proteinase with a mean IC50 of 2.7 nM in JM cells.

Saquinavir (Ro 31-8959) Chemical Structure

Saquinavir (Ro 31-8959) Chemical Structure

CAS: 127779-20-8

Purity & Quality Control

Batch: S962501 DMSO] 100 mg/mL] false] Ethanol] 25 mg/mL] false] Water] Insoluble] false Purity: 99.57%
99.57

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Biological Activity

Description Saquinavir (Ro 31-8959,SAQ) is a potent and selective inhibitor of HIV proteinase with a mean IC50 of 2.7 nM in JM cells.
Targets
HIV proteinase [1]
(in JM cells)
2.7 nM
In vitro
In vitro

Saquinavir (Ro 31-8959) is an effective selective HIV protease inhibitor with an average IC50 of 2.7 nM in JM cells, which inhibits the spread of HIV infection and the production of cytopathic effects.<sup><a class="sref" href="#s_ref">[1]</a></sup>
Cell Research Cell lines JM cells
Concentrations 0.5-100 nM
Incubation Time 3 days
Method

JM cells (2 × 105 cells/ml) were exposed to HIV-1 (GB8) at a multiplicity of infection (MOI) of 0.01 syncytium-forming units/cell. Aliquots (0.2 ml) of cells were placed in microtitre wells with appropriate dilutions of Ro 31-8959 added to 5 replicate cultures. After incubation for 3 days at 37°C in a humidified atmosphere of 5% CO2 in air, syncytia were counted.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06176391 Not yet recruiting Angina Pectoris; Angiospastic Amsterdam UMC location VUmc|ZonMw: The Netherlands Organisation for Health Research and Development January 2 2024 Not Applicable
NCT05997693 Not yet recruiting Chronic Coronary Disease Weill Medical College of Cornell University|Canadian Institutes of Health Research (CIHR) January 2024 Phase 3

Chemical lnformation & Solubility

Molecular Weight 670.84 Formula

C38H50N6O5
CAS No. 127779-20-8 SDF --
Smiles CC(C)(C)NC(=O)C1CC2CCCCC2CN1CC(O)C(CC3=CC=CC=C3)NC(=O)C(CC(N)=O)NC(=O)C4=NC5=CC=CC=C5C=C4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (149.06 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 25 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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