Home JAK/STAT STAT inhibitor SC-1 For research use only.

SC-1

Synonyms: 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7

SC-1 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7), a Sorafenib analogue and potently inhibits the phosphorylation of STAT3, induces cell apoptosis through SHP-1 dependent STAT3 inactivation.

SC-1 Chemical Structure

SC-1 Chemical Structure

CAS: 1313019-65-6

Selleck's SC-1 has been cited by 2 publications

Purity & Quality Control

Batch: S098601 DMSO] 86 mg/mL] false] Ethanol] 86 mg/mL] false] Water] Insoluble] false Purity: 98.02%
98.02

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Biological Activity

Description SC-1 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7), a Sorafenib analogue and potently inhibits the phosphorylation of STAT3, induces cell apoptosis through SHP-1 dependent STAT3 inactivation.
Targets
STAT3 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05477862 Not yet recruiting Alzheimer Disease Northwestern University August 15 2023 Not Applicable
NCT04521231 Recruiting B Cell Precursor Acute Lymphoblastic Leukemia Amgen January 4 2021 Phase 1|Phase 2

Chemical lnformation & Solubility

Molecular Weight 431.8 Formula

C21H13ClF3N3O2
CAS No. 1313019-65-6 SDF --
Smiles FC(F)(F)C1=CC(=CC=C1Cl)NC(=O)NC2=CC=C(OC3=CC=C(C=C3)C#N)C=C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 86 mg/mL ( (199.16 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 86 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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