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Scopolamine HBr trihydrate

Name: Scopolamine HBr trihydrate
Brand: Selleck Chemicals
SKU: S5873

Catalog No.S5873 Purity: 99.40%

Scopolamine HBr is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.

Scopolamine HBr trihydrate Chemical Structure

CAS: 6533-68-2

Purity & Quality Control

Batch: Purity: 99.40%

99.40

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Biological Activity

Description

Scopolamine HBr is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.

Targets

mAChR ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05759481	Not yet recruiting	Post-operative Nausea and Vomiting	Milton S. Hershey Medical Center	January 2024	Phase 2
NCT04999449	Recruiting	Scopolamine\|Motion Sickness	Dartmouth-Hitchcock Medical Center	January 24 2022	Phase 1
NCT04314713	Terminated	Scopolamine Causing Adverse Effects in Therapeutic Use	Battelle Memorial Institute	June 2 2020	Phase 1
NCT03874130	Unknown status	Major Depressive Disorder (MDD)	Repurposed Therapeutics Inc.	August 1 2018	Phase 1
NCT03294109	Completed	Pain Postoperative\|Analgesics Opioid\|Analgesics Non-Narcotic\|Physiological Effects of Drugs\|Peripheral Nervous System Agents\|Patient Satisfaction\|Return to Work\|Activity Sexual	University of California Los Angeles	January 1 2018	Phase 4

Chemical lnformation & Solubility

Molecular Weight	438.31	Formula	C₁₇H₂₈BrNO₇
CAS No.	6533-68-2	SDF	--
Smiles	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4.O.O.O.Br
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 88 mg/mL ( (200.77 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 88 mg/mL

Ethanol : 15 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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