Home Metabolism FXR inhibitor Sevelamer HCl For research use only.

Sevelamer HCl

Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.

Sevelamer HCl Chemical Structure

Sevelamer HCl Chemical Structure

CAS: 152751-57-0

Purity & Quality Control

Batch: Purity: 100%
100

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Biological Activity

Description Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
In Vivo
In vivo Sevelamer is as effective as CaCO3 in reducing serum phosphorus, calcium-phosphorus product, and attenuating secondary hyperparathyroidism in nephrectomized rats (U) fed high phosphorus (HP) diet. Sevelamer results in markedly lower calcium deposition in the myocardium and aorta compared to control rats. [1] Sevelamer suppresses calcification of the aorta media, and also the osteoid volume, fibrosis volume, and porosity ratio of femurs in chronic renal failure rats. [2] Sevelamer results in a significantly lower degree of atherosclerosis and vascular calcification in uremic mice when compared with uremic control mice. Sevelamer exerts an effect on both intima and media calcification in uremic mice. [3] Sevelamer treatment controlled serum P independent of increases in serum Ca, thus reducing serum calcium-phosphate product and further deterioration of renal function, as indicated by the highest creatinine clearances in uremic rats. Sevelamer is as effective as CaCO3 in the control of high-P-induced SH, as shown by similar serum PTH levels, parathyroid (PT) gland weight, and markers of PT hyperplasia. Sevelamer causes a dramatic reduction of renal Ca deposition compared with both uremic + high-P diet (U-HP) and the U-HP+CaCO3 diet. [4] Sevelamer hydrochloride results in a fall in urine pH, as well as an increase in urinary ammonium and calcium excretion consistent with an increase in net acid excretion in animal model. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01220843 Completed Chronic Renal Failure Centre Hospitalier Universitaire Amiens|Genzyme a Sanofi Company October 2010 Phase 3
NCT01191762 Completed Hyperparathyroidism|Chronic Kidney Disease Kenneth R. Phelps M.D.|Genzyme a Sanofi Company|Phelps Kenneth R. M.D. April 2010 Phase 3
NCT01011699 Terminated Chronic Renal Failure|Hemodialysis Centre Hospitalier Universitaire Amiens January 2010 Phase 3
NCT00853242 Completed Kidney Failure Chronic Genzyme a Sanofi Company|Sanofi February 2009 Phase 2

Chemical lnformation & Solubility

Molecular Weight Formula

(C3H7N.C3H5ClO.HCl)x
CAS No. 152751-57-0 SDF Download Sevelamer HCl SDF
Smiles C=CCN.C1C(O1)CCl.Cl
Storage (From the date of receipt)

In vitro
Batch:

4-Methylpyridine : 5 mg/mL

DMSO : 0.005 mg/mL ( ； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
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