Home TGF-beta/Smad TGF-beta/Smad inhibitor SIS3 For research use only.

SIS3

SIS3 is a cell-permeable inhibitor of Smad3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduces TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.

SIS3 Chemical Structure

SIS3 Chemical Structure

CAS: 1009104-85-1

Selleck's SIS3 has been cited by 12 publications

Purity & Quality Control

Batch: Purity: 99.65%
99.65

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Biological Activity

Description SIS3 is a cell-permeable inhibitor of Smad3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduces TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.
Targets
Smad3 [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06096831 Not yet recruiting Stroke|Cerebrovascular Disorders|Cerebrovascular Accident|Healthcare Utilization University of Haifa|Ben-Gurion University of the Negev|Clalit Health Services|Carmel Medical Center November 15 2023 --
NCT05816811 Recruiting Stroke McMaster University August 1 2023 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 453.53 Formula

C28H27N3O3
CAS No. 1009104-85-1 SDF --
Smiles COC1=CC2=C(CN(CC2)C(=O)\C=C\C3=C([N](C)C4=NC=CC=C34)C5=CC=CC=C5)C=C1OC
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 91 mg/mL ( (200.64 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 91 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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