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Sodium ascorbate

Name: Sodium ascorbate
Brand: Selleck Chemicals
SKU: S4245
Rating: 5 (3 reviews)

Synonyms: Sodium Vitamin C

Catalog No.S4245 Purity: 99.81%

Sodium Ascorbate (Sodium Vitamin C) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.

Sodium ascorbate Chemical Structure

CAS: 134-03-2

Selleck's Sodium ascorbate has been cited by 3 publications

Purity & Quality Control

Batch: S424501 Water] 40 mg/mL] false] DMSO] 2 mg/mL] false] Ethanol] Insoluble] false Purity: 99.81%

99.81

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Biological Activity

Description	Sodium Ascorbate (Sodium Vitamin C) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.

In vitro
In vitro	Sodium ascorbate has a growth inhibiting action only at high concentrations in cultured human neoplastic cell lines MCF-7 (breast carcinoma), KB (oral epidermoid carcinoma), and AN3-CA (endometrial adenocarcinoma). Sodium ascorbate combined with vitamin K3 demonstrates a synergistic inhibition of cell growth at 10 to 50 times lower concentrations in cultured human neoplastic cell lines MCF-7, KB, and AN3-CA, at this level separately given vitamins are not toxic. This tumor cell growth inhibitory effect is completely suppressed by the addition of catalase to the culture medium containing vitamins C and K3, suggesting an excessive production of hydrogen peroxide as being implied in mechanisms responsible for the above-mentioned effects. ^[1] Sodium ascorbate combined with vitamin K3 results in a synergistic effect on growth inhibition in cultured human endometrial adenocarcinoma (AN3CA) cells. ^[2] Sodium ascorbate results in a rapid increase in the intracellular concentration of Ca²⁺ ions and subsequent apoptotic cell death in HL-60 cells, characterized by cell shrinkage, nuclear fragmentation and cleavage of internucleosomal DNA to yield fragments that are multiples of 180-200 base pairs, are induced. ^[3] Sodium ascorbate (100 μM) induces DNA single-strand breaks in human cells, Fibroblasts and Molt-4 cells are significantly more sensitive than lymphocytes. Sodium ascorbate (50 μM) results in significant cell loss in Molt-4 cells, but not in lymphocyte and fibroblast cultures. ^[4]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05842382	Not yet recruiting	Pneumonia	Clinical Research Centre Malaysia\|Ain Medicare Sdn Bhd	December 2023	Phase 2
NCT04634227	Recruiting	Sarcoma\|Soft Tissue Sarcoma\|Unresectable Soft Tissue Sarcoma\|Metastatic Bone Tumor\|Bone Sarcoma	Mohammed Milhem\|University of Iowa Adolescent and Young Adult (AYA) Cancer Program\|St. Baldrick''s Foundation\|University of Iowa	November 24 2020	Early Phase 1
NCT03508726	Active not recruiting	Soft Tissue Sarcoma	Mohammed Milhem\|University of Iowa	June 27 2019	Phase 1\|Phase 2
NCT02107976	Recruiting	Diabetes Type 2	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)\|National Institutes of Health Clinical Center (CC)	June 14 2019	Phase 1
NCT03123107	Completed	Coronary Artery Bypass Graft Surgery	Geisinger Clinic\|Wilkes University	July 6 2017	Phase 1
NCT02342405	Completed	Endothelial Dysfunction	Zealand University Hospital	January 2015	Not Applicable

References

[4] Singh NP, et al. Mutat Res, 1997, 375(2), 195-203.

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Chemical lnformation & Solubility

Molecular Weight	198.11	Formula	C₆H₇NaO₆
CAS No.	134-03-2	SDF	Download Sodium ascorbate SDF
Smiles	C(C(C1C(=C(C(=O)O1)O)[O-])O)O.[Na+]
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 40 mg/mL

DMSO : 2 mg/mL ( (10.09 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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