Home NF-κB NF-κB inhibitor Sodium salicylate For research use only.

Sodium salicylate

Synonyms: 2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt

Sodium salicylate(2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt) is used in medicine as an analgesic and antipyretic.

Sodium salicylate Chemical Structure

Sodium salicylate Chemical Structure

CAS: 54-21-7

Selleck's Sodium salicylate has been cited by 1 publication

Purity & Quality Control

Batch: S313701 DMSO] 32 mg/mL] false] Water] 32 mg/mL] false] Ethanol] Insoluble] false Purity: 99.98%
99.98

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Biological Activity

Description Sodium salicylate(2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt) is used in medicine as an analgesic and antipyretic.
Targets
NF-κB [1]
In vitro
In vitro

Sodium salicylate acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. Sodium salicylate inhibits the activation of NF-kappa B, and also inhibits NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells. [1] Sodium salicylate also induces apoptosis via p38 MAPK and inhibits TNF-induced JNK/stress-activated protein kinase activation. [2]

Chemical lnformation & Solubility

Molecular Weight 161.11 Formula

C7H6O3.Na
CAS No. 54-21-7 SDF Download Sodium salicylate SDF
Smiles C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 32 mg/mL ( (198.62 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 32 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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