Home Microbiology Anti-infection chemical Sodium Tauroursodeoxycholate (TUDC) For research use only.

Sodium Tauroursodeoxycholate (TUDC)

Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.

Sodium Tauroursodeoxycholate (TUDC) Chemical Structure

Sodium Tauroursodeoxycholate (TUDC) Chemical Structure

CAS: 35807-85-3

Selleck's Sodium Tauroursodeoxycholate (TUDC) has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 99.47%
99.47

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Biological Activity

Description Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.
In vitro
In vitro In vitro, Tauroursodeoxycholate shows protective and reversing effects on 17βEG-induced impairment of the cVA-of-CLF. [1] In Mz-ChA-1 cholangiocarcinoma cells, Tauroursodeoxycholate inhibits cell growth via Ca2+-, PKC-, and MAPK-dependent pathways. [3] In isolated rat hepatocytes, Tauroursodeoxycholate inhibits bile acid-Induced Apoptosis via a β1-integrin-mediated formation of cAMP. [4]
Cell Research Cell lines Mz-ChA-1 cells
Concentrations ~200 μM
Incubation Time 96 h
Method After trypsinization, Mz-ChA-1 cells are suspended in CCM at 5 × 104 cells/mL, and 200 μL of the cell suspension are seeded into flat-bottomed 96-well plates. After an initial incubation step of 4 h at 37°C in a 5% CO2 incubator, the cells are incubated at 37°C with TUDCA (0.2–200 μM). After incubation for 24–96 h, [3H]thymidine is put into each well at 5.0 μCi/mL and incubated for additional 4 h. [3H]thymidine incorporation is measured by a scintillation counter. At the end of each incubation period, cell viability is evaluated by trypan blue exclusion.
In Vivo
In vivo In phalloidin-induced cholestasis rats, Tauroursodeoxycholate (360 μmol/kg, i.v.) significantly suppresses the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations. [2]
Animal Research Animal Models Phalloidin-induced cholestasis rats
Dosages 360 μmol/kg
Administration i.v.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05753852 Recruiting Amyotrophic Lateral Sclerosis Humanitas Mirasole SpA|University of Ulm|University of Sheffield|University Hospital Tours|KU Leuven|UMC Utrecht|University of Dublin Trinity College|Bruschettini S.r.l.|Istituto Superiore di Sanità|Motor Neurone Disease Association October 25 2021 Phase 3
NCT04114292 Unknown status Ulcerative Colitis Washington University School of Medicine|Crohn''s and Colitis Foundation January 17 2019 Phase 1

Chemical lnformation & Solubility

Molecular Weight 521.69 Formula

C26H44NNaO6S
CAS No. 35807-85-3 SDF Download Sodium Tauroursodeoxycholate (TUDC) SDF
Smiles CC(CCC(=O)NCCS(=O)(=O)[O-])C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C.[Na+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (191.68 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 46 mg/mL


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Frequently Asked Questions

Question 1:
What’s the difference between TUDC (S7896) and TUDCA (S3654)?

Answer:
Our product TUDC is the sodium salt of TUDCA.

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