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SP-8356

SP-8356, an anti-inflammatory synthetic verbenone derivative, is a CD147 inhibitor with respect to its regulation of breast cancer cell behavior and cancer progression.

SP-8356 Chemical Structure

SP-8356 Chemical Structure

CAS: 1454885-45-0

Selleck's SP-8356 has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.01%
99.01

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Biological Activity

Description SP-8356, an anti-inflammatory synthetic verbenone derivative, is a CD147 inhibitor with respect to its regulation of breast cancer cell behavior and cancer progression.
In vitro
In vitro

SP-8356, a synthetic anti-inflammatory verbenone derivative, exerts remarkable anti-atherosclerotic effects through inhibiting CD147-CypA interactions and reducing CypA-induced MMP-9 activation and monocyte adhesion.[2]
In Vivo
In vivo

SP-8356 suppresses collagenase activity, MMP-9, and CypA, preventing the formation of plaque and attenuates its vulnerability in mice models of atherosclerosis.[2]
Animal Research Animal Models ApoE KO mice
Dosages 50 mg/kg
Administration p.o.

Chemical lnformation & Solubility

Molecular Weight 300.35 Formula

C18H20O4
CAS No. 1454885-45-0 SDF --
Smiles COC1=C(O)C(=CC(=C1)/C=C/C2=CC(=O)C3CC2C3(C)C)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 60 mg/mL ( (199.76 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 60 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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