Home GPCR & G Protein Endothelin Receptor antagonist - Angiotensin Receptor antagonist Sparsentan (PS-433540, RE-021) For research use only.

Sparsentan (PS-433540, RE-021)

Synonyms: DARA

Sparsentan (PS-433540, RE-021, DARA) is a dual endothelin type A receptor(ETA) and angiotensin II type 1 receptor antagonist.

Sparsentan (PS-433540, RE-021) Chemical Structure

Sparsentan (PS-433540, RE-021) Chemical Structure

CAS: 254740-64-2

Selleck's Sparsentan (PS-433540, RE-021) has been cited by 2 publications

Purity & Quality Control

Batch: S666501 DMSO] 100 mg/mL] false] Ethanol] 40 mg/mL] false] Water] Insoluble] false Purity: 99.71%
99.71

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Biological Activity

Description Sparsentan (PS-433540, RE-021, DARA) is a dual endothelin type A receptor(ETA) and angiotensin II type 1 receptor antagonist.
Targets
endothelin type A receptor [1] angiotensin II type 1 receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05572229 Not yet recruiting Multiple Myeloma University Hospital Lille|Janssen Pharmaceutica N.V. Belgium September 2023 Phase 2
NCT05408026 Withdrawn Relapsed or Refractory Multiple Myeloma Alliance Foundation Trials LLC.|Janssen LP|Celgene October 1 2022 Phase 1|Phase 2
NCT05004259 Recruiting Hemolytic Anemia Dartmouth-Hitchcock Medical Center March 21 2022 Phase 1

Chemical lnformation & Solubility

Molecular Weight 592.75 Formula

C32H40N4O5S
CAS No. 254740-64-2 SDF --
Smiles CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC(=C(C=C3)C4=CC=CC=C4S(=O)(=O)NC5=NOC(=C5C)C)COCC
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (168.7 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 40 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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