Home Microbiology Antibiotics chemical Spiramycin For research use only.

Spiramycin

Synonyms: Formacidine

Spiramycin (Formacidine) is a 16-membered ring macrolide (antibiotic).

Spiramycin Chemical Structure

Spiramycin Chemical Structure

CAS: 8025-81-8

Selleck's Spiramycin has been cited by 1 publication

Purity & Quality Control

Batch: S408201 DMSO] 157 mg/mL] false] Ethanol] 157 mg/mL] false] Water] Insoluble] false Purity: >97%
97

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Biological Activity

Description Spiramycin (Formacidine) is a 16-membered ring macrolide (antibiotic).
In vitro
In vitro Spiramycin reduces the hygromycin A protections of nucleotides in 23 S rRNA. [1] Spiramycin, a 16-membered macrolide, inhibits translocation by binding to bacterial 50S ribosomal subunits with an apparent 1:1 stoichiometry. Spiramycin acts primarily by stimulating the dissociation of peptidyl-tRNA from ribosomes during translocation. [2] Spiramycin at doses sufficient to inhibit protein synthesis in wild-type cells but not sufficient to kill either mutant or wild-type cells at the permissive temperature (30 degrees C). Spiramycin inhibits protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. [3] Spiramycin shows dose-related inhibition of the proliferative response of PHA and PWM stimulated human mononuclear leucocytes (MNL). Spiramycin also induces a decrease in tritiated uridine (3H-UdR) uptake, which suggests that Spiramycin interferes with an early event in the cell cycle. [4] Spiramycin and, to a lesser extent, erythromycin increases total IL-6 production without affecting IL-1 alpha, IL-1 beta, or tumor necrosis factor alpha production in human monocytes stimulated with lipopolysaccharide. [5] Spiramycin shows good antimicrobial activity against species of Prevotella, Eubacterium, Peptostreptococcus, Bacteroides and Porphyromonas, and the effect is enhanced by the addition of Metronidazole. [6]

Chemical lnformation & Solubility

Molecular Weight 843.05 Formula

C43H74N2O14
CAS No. 8025-81-8 SDF Download Spiramycin SDF
Smiles CC1CC=CC=CC(C(CC(C(C(C(CC(=O)O1)O)OC)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)OC4CCC(C(O4)C)N(C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 157 mg/mL ( (186.22 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 157 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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