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Tafluprost

Name: Tafluprost
Brand: Selleck Chemicals
SKU: S4851

Synonyms: AFP-168,MK2452

Catalog No.S4851 Purity: 99.02%

Tafluprost (AFP-168,MK2452) is a novel prostaglandin analog with a high affinity for the fluoroprostaglandin (FP) receptor PGF2α. A prostanoid selective FP receptor agonist.

Tafluprost Chemical Structure

CAS: 209860-87-7

Purity & Quality Control

Batch: S485101 Purity: 99.02%

99.02

Related compound libraries

Choose Selective Prostaglandin Receptor Inhibitors

Biological Activity

Description

Tafluprost (AFP-168,MK2452) is a novel prostaglandin analog with a high affinity for the fluoroprostaglandin (FP) receptor PGF2α. A prostanoid selective FP receptor agonist.

Targets

PGF2α ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT04828057	Completed	Ocular Surface Disease\|Primary Open Angle Glaucoma	Santen Pharmaceutical (Taiwan) Co. LTD	September 1 2021	--
NCT03612817	Completed	Glaucoma Open-Angle	Aristotle University Of Thessaloniki\|Santen Oy	January 2017	Phase 4
NCT02102750	Completed	Glaucoma\|Ocular Hypertension	Santen Oy	June 2014	Phase 1
NCT03104621	Completed	Primary Open-angle Glaucoma	Gangnam Severance Hospital	March 2013	Phase 4

References

[1] Krupa M, et al. Molecules. 2017, 22(2).

Chemical lnformation & Solubility

Molecular Weight	452.53	Formula	C₂₅H₃₄F₂O₅
CAS No.	209860-87-7	SDF	--
Density	1.186 g/mL
Smiles	CC(C)OC(=O)CCCC=CCC1C(CC(C1C=CC(COC2=CC=CC=C2)(F)F)O)O
Storage (From the date of receipt)	2 years -80°C liquid	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	2 years -80°C liquid		1 month-20°Cin solvent

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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