Home DNA Damage/DNA Repair OGG1 agonist TH10785 For research use only.

TH10785

TH10785 controls the catalytic activity mediated by a nitrogen base within molecular structure of cells and increases 8-oxoguanine DNA glycosylase 1 (OGG1) recruitment and repair of oxidative DNA damage.

TH10785 Chemical Structure

TH10785 Chemical Structure

CAS: 1002801-51-5

Purity & Quality Control

Batch: E127701 DMSO] 53 mg/mL] false] Ethanol] 53 mg/mL] false] Water] Insoluble] false Purity: 99.83%
99.83

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Biological Activity

Description TH10785 controls the catalytic activity mediated by a nitrogen base within molecular structure of cells and increases 8-oxoguanine DNA glycosylase 1 (OGG1) recruitment and repair of oxidative DNA damage.
Targets
OGG1 [1]

Chemical lnformation & Solubility

Molecular Weight 267.37 Formula

C17H21N3
CAS No. 1002801-51-5 SDF --
Smiles C1CCC(CC1)NC2=NC(=NC3=C2C=CC=C3)C4CC4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 53 mg/mL ( (198.22 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 53 mg/mL

Water : Insoluble


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In vivo
Batch:

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Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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