Home Neuronal Signaling GABA Receptor inhibitor Tiagabine hydrochloride For research use only.

Tiagabine hydrochloride

Synonyms: Gabitril hydrochloride, NO050328 hydrochloride, NO328 hydrochloride, TGB hydrochloride

Tiagabine Hydrochloride (Gabitril, NO050328, NO328, TGB) is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.

Tiagabine hydrochloride Chemical Structure

Tiagabine hydrochloride Chemical Structure

CAS: 145821-59-6

Purity & Quality Control

Batch: S466101 DMSO] 82 mg/mL] false] Ethanol] 82 mg/mL] false] Water] 11 mg/mL] false Purity: 99.78%
99.78

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Biological Activity

Description Tiagabine Hydrochloride (Gabitril, NO050328, NO328, TGB) is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
Targets
GABA uptake [1]
In vitro
In vitro Tiagabine is a potent inhibitor of GABA uptake into neurons and glial cells. It is involved in modulating GABA levels, especially in areas such as the hippocampus and thalamus[2]. Tiagabine not only affected the decay kinetics of the IPSCs, it also reduced the frequency of occurrence of both spontaneous and miniature IPSCs[4].
In Vivo
In vivo Tiagabine offers a significant neuroprotection in global ischemia in gerbils when given 30 min before ischemia but not when given 3 h after ischemia[3].
Animal Research Animal Models Male adult Sprague-Dawley rats
Dosages 0.2 μmol
Administration microinjected unilaterally into the globus pallidus

Chemical lnformation & Solubility

Molecular Weight 412.01 Formula

C20H25NO2S2.HCl
CAS No. 145821-59-6 SDF Download Tiagabine hydrochloride SDF
Smiles CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 82 mg/mL ( (199.02 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 82 mg/mL

Water : 11 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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