Home GPCR & G Protein Glucagon Receptor Tirzepatide (LY3298176) sodium For research use only.

Tirzepatide (LY3298176) sodium

Tirzepatide (LY3298176, GIP/GLP-1 RA, TZP) sodium is a dual GIP/GLP-1 receptor agonist. Tirzepatide differentially induces internalization of the GIP and GLP-1 receptors with EC50 values of 18.2 nM and 18.1 nM, respectively.

Tirzepatide (LY3298176) sodium Chemical Structure

Tirzepatide (LY3298176) sodium Chemical Structure

CAS: 2023788-19-2 (free base)

Selleck's Tirzepatide (LY3298176) sodium has been cited by 4 publications

Purity & Quality Control

Batch: Purity: 99.96%
99.96

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Biological Activity

Description Tirzepatide (LY3298176, GIP/GLP-1 RA, TZP) sodium is a dual GIP/GLP-1 receptor agonist. Tirzepatide differentially induces internalization of the GIP and GLP-1 receptors with EC50 values of 18.2 nM and 18.1 nM, respectively.
Targets
GLP-1 receptor [1] GIP receptor [1]
18.1 nM(EC50) 18.2 nM(EC50)
In vitro
In vitro

In HEK293 cells, Tirzepatide induces internalization of the GIPR and has a propensity toward partial agonism, and this ultimately reflects in signaling bias toward the cAMP pathway versus β-arrestin recruitment.[1]
In Vivo
In vivo

LY3298176 shows glucose-dependent insulin secretion and improves glucose tolerance by acting on both GIP and GLP-1 receptors in mice. Chronic treatment with LY3298176 results in a significant dose-dependent decrease in body weight that is more pronounced than that observed with semaglutide.[2]

Chemical lnformation & Solubility

Molecular Weight 4813.45 Formula

C225H348N48O68• XNa
CAS No. 2023788-19-2 (free base) SDF --
Density 95.0~105.0%
Storage (From the date of receipt) 3 years-20°C powder Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

In vitro
Batch:

DMSO : 100 mg/mL ( (20.77 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble


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In vivo
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