Home Transmembrane Transporters Sodium Channel inhibitor Tolperisone HCl For research use only.

Tolperisone HCl

Tolperisone HCl is an ion channel blocker and centrally-acting muscle relaxant.

Tolperisone HCl Chemical Structure

Tolperisone HCl Chemical Structure

CAS: 3644-61-9

Purity & Quality Control

Batch: S420001 DMSO] 56 mg/mL] false] Water] 56 mg/mL] false] Ethanol] 56 mg/mL] false Purity: 99.98%
99.98

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Biological Activity

Description Tolperisone HCl is an ion channel blocker and centrally-acting muscle relaxant.
Targets
Sodium channel [1]
In vitro
In vitro Tolperisone reduces sodium and potassium permeability in the node of Ranvier of frogs, blocks calcium currents in snail neurons and inhibits current through heterologously expressed Nav1.6 channels. [1] Tolperisone hydrochloride represents an effective and safe treatment of painful reflex muscle spasm without the typical side effects of centrally active muscle relaxants. [2]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05544656 Recruiting Low Back Pain Semmelweis University|National Research Develpment and Innovation Fund Hungary|MEDITOP Pharmaceutical LTD Hungary December 13 2019 Phase 3
NCT00532532 Terminated Muscle Spasticity Avigen September 2007 Phase 2

Chemical lnformation & Solubility

Molecular Weight 281.82 Formula

C16H23NO.HCl
CAS No. 3644-61-9 SDF Download Tolperisone HCl SDF
Smiles CC1=CC=C(C=C1)C(=O)C(C)CN2CCCCC2.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 56 mg/mL ( (198.7 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 56 mg/mL

Ethanol : 56 mg/mL


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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