Home Metabolism MAO inhibitor Tranylcypromine HCl For research use only.

Tranylcypromine HCl

Synonyms: 2-PCPA HCl, SKF-385 HCl

Tranylcypromine HCl is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.

Tranylcypromine HCl Chemical Structure

Tranylcypromine HCl Chemical Structure

CAS: 1986-47-6

Selleck's Tranylcypromine HCl has been cited by 16 Publications

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Purity & Quality Control

Batch: Purity: 99.91%
99.91

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Biological Activity

Description Tranylcypromine HCl is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.
Targets
MAO-B [5]
(Cell-free assay)		 MAO-A [1]
(Cell-free assay)		 LSD1 [5]
(Cell-free assay)
7 μM 11.5 μM 22.3 μM
In vitro
In vitro R-(+)-Tranylcypromine, (±)-Tranylcypromine, and S-(−)-Tranylcypromine competitively inhibits CYP2A6-mediated metabolism of nicotine with apparent Ki values of 0.05 μM, 0.08 μM, and 2.0 μM, respectively, in human liver microsomes. [1] Tranylcypromine (500 μg/mL) severely inhibits bradykinin-stimulated arachidonic acid release in calf aortic endothelial cells. [2] Tranylcypromine inhibits CYP2A6 and CYP2E1 activity with IC50 of 0.42 μM and 3 μM, respectively, in human liver microsomes. Tranylcypromine induces type II and cyclopropylbenzene type I difference spectrum in human liver microsomes. [3]
In Vivo
In vivo Tranylcypromine injection leads to a large, slow increase in motor activity at 5 mg/kg and 10 mg/kg compared with the saline control in male rats, although 2 mg/kg Tranylcypromine does not induce an increase. Tranylcypromine (10 mg/kg) also causes significant decreases in the number of rearing behaviors in male rats. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04841798 Completed Major Depressive Disorder|Treatment Resistant Depression Centre for Addiction and Mental Health April 15 2021 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 169.65 Formula

C9H12ClN
CAS No. 1986-47-6 SDF Download Tranylcypromine HCl SDF
Smiles C1C(C1N)C2=CC=CC=C2.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 34 mg/mL ( (200.41 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 34 mg/mL

Ethanol : 34 mg/mL


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In vivo
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