Home Angiogenesis HER2 inhibitor - Microtubule Associated inhibitor - Antibody-Drug Conjugate Trastuzumab-Emtansine（T-DM1） For research use only.

Trastuzumab-Emtansine（T-DM1）

Synonyms: Ado-Trastuzumab emtansine

Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.Trastuzumab emtansine has a molecular weight of 145kDa.This product is supplied as 10mg/ml PBS solution. This product is discontinued. We recommend the replacement products: D4003

Trastuzumab-Emtansine（T-DM1） Chemical Structure

Trastuzumab-Emtansine（T-DM1） Chemical Structure

CAS: 1018448-65-1 (ADC)

Click to purchase the isotype control of Trastuzumab Emtansine（T-DM1）

Purity & Quality Control

Batch: E285101 Purity: 99.59%
99.59

Products often used together with Trastuzumab-Emtansine（T-DM1）

Tucatinib

Trastuzumab Emtansine and Tucatinib show antitumor activity in ERBB2/HER2-positive metastatic breast cancer with and without brain metastases.

Borges VF, et al. JAMA Oncol. 2018 Sep 1;4(9):1214-1220.

Osimertinib (AZD9291)

Trastuzumab Emtansine and Osimertinib may be a promising therapeutic strategy for EGFR-mutant NSCLC.

Monica SL, et al. J Exp Clin Cancer Res. 2017 Dec 4;36(1):174.

Ribociclib

Trastuzumab Emtansine and Ribociclib are under clinical trials for HER2-positive metastatic breast cancer.

Spring LM, et al. NPJ Breast Cancer. 2021 Aug 4;7(1):103.

Lapatinib

Trastuzumab Emtansine has better overall survival and PFS when compared with Lapatinib for treating HER2-Positive, unresectable, locally advanced or metastatic breast cancer.

Squires H, et al. Pharmacoeconomics. 2016 Jul;34(7):673-80.

Capecitabine

Addition of Capecitabine to Trastuzumab Emtansine increases toxic effects.

Cortes J, et al. JAMA Oncol. 2020 Aug 1;6(8):1203-1209.

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Biological Activity

Description Trastuzumab Emtansine(T-DM1,Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1.Trastuzumab emtansine has a molecular weight of 145kDa.This product is supplied as 10mg/ml PBS solution. This product is discontinued. We recommend the replacement products: D4003
Targets
HER2 [1] Microtubule [1]
In vitro
In vitro

Trastuzumab emtansine significantly inhibits the proliferation of epithelial ovarian cancer (EOC) cells.
Cell Research Cell lines EOC cells
Concentrations 2 μg/ml
Incubation Time 24 h
Method

Cells were treated with various concentrations of drug for 24 h.

Chemical lnformation & Solubility

Molecular Weight 145000 Formulation 10mg/mL in PBS
DAR 3.6 Antibody Trastuzumab
ADC Cytotoxin DM1 Formula N/A
CAS No. 1018448-65-1 (ADC) Storage (From the date of receipt) 1 year -80°C in solvent
Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
What’s the solvent of this ADC drug? And what’s its concentration?

Answer:
The solvent is a PBS solution. The concentration is 10mg/ml.

HER2 Signaling Pathway Map

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