Home Transmembrane Transporters Sodium Channel inhibitor Triamterene For research use only.

Triamterene

Synonyms: SKF8542

Triamterene (SKF8542) blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.

Triamterene Chemical Structure

Triamterene Chemical Structure

CAS: 396-01-0

Selleck's Triamterene has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.91%
99.91

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Biological Activity

Description Triamterene (SKF8542) blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.
Targets
ENaC [1] ENaCαS583 [1]
4.5 μM 23.9 μM
In vitro
In vitro Triamterene inhibits the epithelial sodium channels on principal cells in the late distal convoluted tubule and collecting tubule, which are responsible for 1-2% of total sodium reabsorption. Triamterene can achieve a modest amount of diuresis by decreasing the osmotic gradient necessary for water reabsorption from lumen to interstitium. Triamterene also has a potassium-sparing effect. Normally, the process of potassium excretion is driven by the electrochemical gradient produced by sodium reabsorption. As sodium is reabsorbed, it leaves a negative potential in the lumen, while producing a positive potential in the principal cell. This potential promotes potassium excretion through apical potassium channels. By inhibiting sodium reabsorption, triamterene also inhibits potassium excretion. [2]
In Vivo
In vivo 4'-hydroxylation of triamterene in humans appears to be mediated exclusively by CYP1A2. Inhibition or induction of CYP1A2 will change the time course of both triamterene and its active phase-II metabolite.[3]

Chemical lnformation & Solubility

Molecular Weight 253.26 Formula

C12H11N7
CAS No. 396-01-0 SDF Download Triamterene SDF
Smiles C1=CC=C(C=C1)C2=NC3=C(N=C(N=C3N=C2N)N)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 5 mg/mL ( (19.74 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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