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Tropicamide

Name: Tropicamide
Brand: Selleck Chemicals
SKU: S1913

Synonyms: Ro 1-7683

Catalog No.S1913 Purity: 100.00%

Tropicamide(Ro 1-7683) is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.

Tropicamide Chemical Structure

CAS: 1508-75-4

Purity & Quality Control

Batch: S191301 DMSO] 57 mg/mL] false] Ethanol] 57 mg/mL] false] Water] Insoluble] false Purity: 100.00%

100.00

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Biological Activity

Description

Tropicamide(Ro 1-7683) is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.

Targets

M4 mAChR ^[1]

8 nM

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06148051	Recruiting	Cadasil	Perminder Sachdev\|Prince of Wales Hospital Sydney\|John Hunter Hospital\|St Vincent''s Hospital - Sydney Australia\|Royal Brisbane and Women''s Hospital\|Melbourne Health\|The University of Queensland\|The University of New South Wales	November 25 2023	--
NCT06077682	Recruiting	Cycloplegia\|Refractive Errors\|Esotropia\|Vision Disorders	Islamic Hospital Jordan\|Jordan University of Science and Technology\|Yarmouk University	September 1 2023	Phase 4
NCT05442801	Completed	Cycloplegia	Islamic Hospital Jordan	March 1 2022	Phase 4

Chemical lnformation & Solubility

Molecular Weight	284.35	Formula	C₁₇H₂₀N₂O₂
CAS No.	1508-75-4	SDF	Download Tropicamide SDF
Smiles	CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 57 mg/mL ( (200.45 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 57 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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