Home Neuronal Signaling AChR antagonist Umeclidinium bromide For research use only.

Umeclidinium bromide

Synonyms: GSK573719A

Umeclidinium bromide(GSK573719A) is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD).

Umeclidinium bromide Chemical Structure

Umeclidinium bromide Chemical Structure

CAS: 869113-09-7

Purity & Quality Control

Batch: S373501 DMSO] 100 mg/mL] false] Ethanol] 12 mg/mL] false] Water] Insoluble] false Purity: 99.81%
99.81

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Biological Activity

Description Umeclidinium bromide(GSK573719A) is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD).
Targets
mAChR [1]
In vitro
In vitro

Umeclidinium is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium for the cloned human M1-M5 mAChRs ranged from 0.05 to 0.16 nM[1].
In Vivo
In vivo

Umeclidinium is a potent anticholinergic agent that demonstrates slow functional reversibility at the human M3 mAChR and long duration of action in animal models[1].

Chemical lnformation & Solubility

Molecular Weight 508.49 Formula

C29H34NO2.Br
CAS No. 869113-09-7 SDF Download Umeclidinium bromide SDF
Smiles C1C[N+]2(CCC1(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCOCC5=CC=CC=C5.[Br-]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (196.66 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 12 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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