Home Neuronal Signaling Serotonin Transporter inhibitor Venlafaxine For research use only.

Venlafaxine

Synonyms: Wy 45030

Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.

Venlafaxine Chemical Structure

Venlafaxine Chemical Structure

CAS: 93413-69-5

Purity & Quality Control

Batch: S565501 DMSO] 55 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.49%
99.49

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Biological Activity

Description Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.
Targets
serotonin-norepinephrine reuptake [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06131268 Recruiting Major Depressive Disorder|Bipolar Affective Disorder Currently Depressed Moderate Fondazione IRCCS Ca'' Granda Ospedale Maggiore Policlinico March 1 2022 Phase 4
NCT04708834 Enrolling by invitation Obsessive Compulsive Disorder Biohaven Pharmaceuticals Inc. March 30 2021 Phase 3
NCT03532477 Recruiting Obesity Morbid Norwegian University of Science and Technology|St. Olavs Hospital|Volvat Medisinsk Senter Stokkan|Namsos Hospital|Alesund Hospital November 2 2016 --
NCT02637193 Completed Healthy Subjects Pfizer''s Upjohn has merged with Mylan to form Viatris Inc.|Pfizer December 2015 Phase 1
NCT02005107 Completed Roux en Y Gastric Bypass|Sleeve Gastrectomy North Dakota State University|Neuropsychiatric Research Institute Fargo North Dakota December 2013 Phase 4
NCT01867255 Completed Bariatric Surgery|Gastric Bypass|Roux-en-Y Gastric Bypass Mayo Clinic October 2013 Phase 1

Chemical lnformation & Solubility

Molecular Weight 277.40 Formula

C17H27NO2
CAS No. 93413-69-5 SDF --
Smiles CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 55 mg/mL ( (198.26 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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