Home Metabolism Vitamin chemical Vitamin A Acetate For research use only.

Vitamin A Acetate

Synonyms: Retinyl (Retinol) Acetate

Vitamin A Acetate (Retinyl, Retinol) is a group of unsaturated nutritional hydrocarbons, that includes retinol, retinal, retinoic acid, and several provitamin A carotenoids, among which beta-carotene is the most important.

Vitamin A Acetate Chemical Structure

Vitamin A Acetate Chemical Structure

CAS: 127-47-9

Selleck's Vitamin A Acetate has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.62%
99.62

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Biological Activity

Description Vitamin A Acetate (Retinyl, Retinol) is a group of unsaturated nutritional hydrocarbons, that includes retinol, retinal, retinoic acid, and several provitamin A carotenoids, among which beta-carotene is the most important.
In vitro
In vitro Vitamin A deficiency impairs innate immunity by impeding normal regeneration of mucosal barriers damaged by infection, and by diminishing the function of neutrophils, macrophages, and natural killer cells. Vitamin A is also required for adaptive immunity and plays a role in the development of T both-helper (Th) cells and B-cells. Vitamin A deficiency diminishes antibody-mediated responses directed by Th2 cells, although some aspects of Th1-mediated immunity are also diminished. [1]
In Vivo
In vivo Vitamin A acetate (VAA) (fed on an otherwise conventional diet) responds to 105 semiallogeneic cells (a suboptimal dose) in a host-versus-graft (HvG) reaction in mice, whereas mice on a conventional diet do not. [2] Vitamin A acetate can bring a solid and long-lasting state of tolerance induced by the intravenous injection into newborn CBA mice of lymphoid cells from (CBA X C57BL/10ScSn) F1 hybrids to an end, the effect of which is to increase the proportion of the moiety of the T-cell population that produces IL-2. [3] Vitamin A acetate-supplemented diet develops a positive skin reaction to purified protein derivative of mycobacteria in High-dose Mycobacterium bovis-infected mice, and their spleen cells show an increased IL-2 production in vitro. [4]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06057597 Recruiting Obesity|Morbid Assistance Publique - Hôpitaux de Paris November 13 2023 Not Applicable
NCT06081114 Recruiting Micronutrient Status Johns Hopkins Bloomberg School of Public Health|International Center for Diarrheal Disease Research Bangladesh (icddrb)|Bill and Melinda Gates Foundation October 22 2023 Not Applicable
NCT06058442 Not yet recruiting Gastrectomy University of Leipzig October 2023 Phase 3
NCT06155448 Active not recruiting Malaria Malaria Consortium|Nigerian Institute of Medical Research|London School of Hygiene and Tropical Medicine|Northwestern University August 8 2023 Not Applicable
NCT05045703 Withdrawn Choroideremia Duke University|Foundation Fighting Blindness May 2023 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 328.49 Formula

C22H32O2
CAS No. 127-47-9 SDF Download Vitamin A Acetate SDF
Smiles CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CCOC(=O)C)C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 65 mg/mL ( (197.87 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 65 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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