Home Cell Cycle Wee1 inhibitor Azenosertib (Zn-C3) For research use only.

Azenosertib (Zn-C3)

Azenosertib (Zn-C3) is an oral active, highly effective and selective Wee1 inhibitor with IC50 of 3.9 nM, which can be used in cancer research.

Azenosertib (Zn-C3) Chemical Structure

Azenosertib (Zn-C3) Chemical Structure

CAS: 2376146-48-2

Selleck's Azenosertib (Zn-C3) has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.81%
99.81

Products often used together with Azenosertib (Zn-C3)

Adavosertib (MK-1775)

ZN-c3 has a higher selectivity and better safety profiles compared to Adavosertib, making it particularly well-suited for combination therapies.

Bukhari AB, et al. Front Oncol. 2022 Feb 17;12:828684.

Pembrolizumab (anti-PD-1)

ZN-c3 an orally administered WEE1 inhibitor is under investigation in phase I/II study in combination with pembrolizumab for solid cancers including Small cell lung cancer (SCLC).

Guo H, et al. J Thorac Dis. 2020 Oct;12(10):6070-6089.

Gemcitabine

ZN-c3 potentiates the antitumor efficacy of gemcitabine.

Li J, et al. Cancer Res (2021) 81 (13_Supplement): 1965.

Niraparib (MK-4827)

Zn-C3 and Niraparib combination therapy is used to treat Platinum-resistant ovarian cancer.

Alli VJ, et al. ACS Omega. 2023 Jun 2;8(23):20196-20233.

RP-6306

Zn-C3 and RP-306 combined inhibition of WEE1 and PKMYT1 exhibits synergism in killing of U2OS cells.

Benada J, et al. NAR Cancer. 2023 Jun 13;5(3):zcad029.

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Biological Activity

Description Azenosertib (Zn-C3) is an oral active, highly effective and selective Wee1 inhibitor with IC50 of 3.9 nM, which can be used in cancer research.
Targets
Wee1 [1]
3.9 nM

Chemical lnformation & Solubility

Molecular Weight 526.63 Formula

C29H34N8O2
CAS No. 2376146-48-2 SDF --
Smiles CCC1(O)CCC2=CC=C(N=C12)N3N(CC=C)C(=O)C4=CN=C(NC5=CC=C(C=C5)N6CCN(C)CC6)N=C34
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (189.88 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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