Home NF-κB NF-κB inhibitor (R)-(-)-Ibuprofen For research use only.

(R)-(-)-Ibuprofen

Synonyms: (R)-Ibuprofen

(R)-(-)-Ibuprofen ((R)-Ibuprofen) inhibits the activation of NF-κB in response to T-cell stimulation with IC50 of 121.8 μM, and exerts anti-inflammatory and antinociceptive effects.

(R)-(-)-Ibuprofen Chemical Structure

(R)-(-)-Ibuprofen Chemical Structure

CAS: 51146-57-7

Purity & Quality Control

Batch: S589901 DMSO] 41 mg/mL] false] Water] 41 mg/mL] false] Ethanol] 41 mg/mL] false Purity: 99.94%
99.94

Other NF-κB Products

Related compound libraries

Choose Selective NF-κB Inhibitors

Biological Activity

Description (R)-(-)-Ibuprofen ((R)-Ibuprofen) inhibits the activation of NF-κB in response to T-cell stimulation with IC50 of 121.8 μM, and exerts anti-inflammatory and antinociceptive effects.
Targets
NF-κB [1]
(Cell-free assay)
121.8 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06146491 Recruiting Pain Postoperative B.P. Koirala Institute of Health Sciences August 10 2023 Phase 4
NCT05928520 Not yet recruiting Pain Management Al-Azhar University August 1 2023 Phase 3
NCT05575700 Recruiting Pain Acute|Hip Arthropathy|Knee Arthropathy|Safety Issues|Analgesia|Analgesic Adverse Reaction|Postoperative Pain|Postoperative Complications Naestved Hospital April 17 2023 Phase 4
NCT05496868 Recruiting Acute Respiratory Distress Syndrome Adult Dompé Farmaceutici S.p.A February 7 2023 Phase 2
NCT05674721 Completed Pain HALEON January 5 2023 Phase 1

Chemical lnformation & Solubility

Molecular Weight 206.28 Formula

C13H18O2
CAS No. 51146-57-7 SDF --
Smiles CC(C)CC1=CC=C(C=C1)C(C)C(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 41 mg/mL ( (198.75 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 41 mg/mL

Ethanol : 41 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy (R)-(-)-Ibuprofen | (R)-(-)-Ibuprofen supplier | purchase (R)-(-)-Ibuprofen | (R)-(-)-Ibuprofen cost | (R)-(-)-Ibuprofen manufacturer | order (R)-(-)-Ibuprofen | (R)-(-)-Ibuprofen distributor