Home Microbiology Antibiotics chemical Cefoselis Sulfate For research use only.

Cefoselis Sulfate

Synonyms: FK 037 Sulfate

Cefoselis (FK 037 Sulfate) is a widely used beta-lactam antibiotic.

Cefoselis Sulfate Chemical Structure

Cefoselis Sulfate Chemical Structure

CAS: 122841-12-7

Purity & Quality Control

Batch: Purity: 99.62%
99.62

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Biological Activity

Description Cefoselis (FK 037 Sulfate) is a widely used beta-lactam antibiotic.
In vitro
In vitro

Cefoselis inhibits GABA-induced currents in a concentration-dependent manner with IC50 of 185 mM. [1] Cefoselis possesses a superior antistaphylococcal activity on MSSA isolates to both other compounds being however equal active to Cefepime and Cefpirome on multiresistant enterobacteriaceae. [2] Cefoselis is dose-dependently appeared in brain extracellular fluid in proportion to its blood level. [3] Cefoselis, a new parenteral cephalosporin, is active against clinical isolates of both gram-positive and gram-negative aerobic bacteria. [4]
In Vivo
In vivo

Cefoselis elicits a massive elevation of extracellular glutamate concentration in normal rats. [3] Cefoselis (50 mg/animal)-induced convulsions are prevented by pretreatment with 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), diazepam and phenobarbital (ED(50) values (mg/kg) of 0.78, 1.59 and 33.0, respectively), but not by carbamazepine or phenytoin. [5]

Chemical lnformation & Solubility

Molecular Weight 620.64 Formula

C19H22N8O6S2.H2SO4
CAS No. 122841-12-7 SDF Download Cefoselis Sulfate SDF
Smiles CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)CN4C=CC(=N)N4CCO)C(=O)O.OS(=O)(=O)O
Storage (From the date of receipt)

In vitro
Batch:

Water : 5 mg/mL

DMSO : 3 mg/mL ( (4.83 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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