Home Transmembrane Transporters Potassium Channel activator Hydralazine HCl For research use only.

Hydralazine HCl

Hydralazine HCl is a hydrochloride salt of hydralazine, which is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles.

Hydralazine HCl Chemical Structure

Hydralazine HCl Chemical Structure

CAS: 304-20-1

Selleck's Hydralazine HCl has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 99.95%
99.95

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Biological Activity

Description Hydralazine HCl is a hydrochloride salt of hydralazine, which is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles.
Targets
Potassium Channel [1]
In vitro
In vitro Hydralazine impairs up-regulation of RAG-2 gene expression and reduces secondary Ig gene rearrangements. Hydralazine subverts B lymphocyte tolerance to self and contributes to generation of pathogenic autoreactivity by disrupting receptor editing. [1] Hydralazine directly scavenges free acrolein, decreasing intracellular acrolein availability and thereby suppressing macromolecular adduction. Hydralazine inhibits cross-linking if adding 30 min after commencing acrolein exposure but is ineffective if added after a 90-min delay. [2] Hydralazine (0.1-10 mM) inhibits both extracellular and intracellular ROS production by inflammatory macrophages, by a ROS-scavenging mechanism probably affecting superoxide radical (O(2)(*-))-generation by xanthine oxidase (XO) and nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate (NADH/NADPH) oxidase. Hydralazine (0.1-10 mM) significantly reduces NO(*) generation, and this effect is attributable to an inhibition of NOS-2 gene expression and protein synthesis. Hydralazine also effectively blocks COX-2 gene expression which perfectly correlated with a reduction of protein levels and PGE(2) synthesis. [3] Hydralazine protects against not only acrolein-mediated injury, but also compression in guinea pig spinal cord ex vivo. Hydralazine can significantly alleviate acrolein-induced superoxide production, glutathione depletion, mitochondrial dysfunction, loss of membrane integrity, and reduces compound action potential conduction. [4]
In Vivo
In vivo Hydralazine affords strong, dose-dependent protection against the increases in plasma marker enzymes but not the hepatic glutathione depletion produced by allyl alcohol in mice. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05096728 Completed Preeclampsia With Severe Features Ohio State University December 1 2021 --
NCT04164004 Active not recruiting Heart Failure Stanford University August 30 2021 Not Applicable
NCT03619317 Unknown status Cancer of Esophagus Aarhus University Hospital Skejby|Danish Cancer Society June 25 2018 --
NCT01587313 Completed Healthy Arbor Pharmaceuticals Inc. April 2012 Phase 1

Chemical lnformation & Solubility

Molecular Weight 196.64 Formula

C8H8N4.HCl
CAS No. 304-20-1 SDF Download Hydralazine HCl SDF
Smiles C1=CC=C2C(=C1)C=NN=C2NN.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 39 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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