Home Neuronal Signaling Histamine Receptor agonist Lidocaine For research use only.

Lidocaine

Synonyms: Alphacaine

Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

Lidocaine Chemical Structure

Lidocaine Chemical Structure

CAS: 137-58-6

Selleck's Lidocaine has been cited by 6 publications

Purity & Quality Control

Batch: S135701 DMSO] 47 mg/mL] false] Ethanol] 47 mg/mL] false] Water] 9 mg/mL] false Purity: 99.97%
99.97

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Biological Activity

Description Lidocaine (Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.
Targets
Histamine H1 receptor [1]
>32 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05402293 Not yet recruiting Acute Pain|Lidocaine|Administration and Dosage University of Alberta January 15 2024 --
NCT04614610 Not yet recruiting Sickle Cell Disease|Sickle Cell Crisis|Pain Acute Community Medical Center Toms River NJ|Newark Beth Israel Medical Center|Monmouth Medical Center|Rutgers Robert Wood Johnson Medical School January 1 2024 Phase 2
NCT06135688 Recruiting Anesthesia Brain Monitoring|Lidocaine University of Padova November 18 2023 --
NCT06122324 Enrolling by invitation Postoperative Sore Throat Dr. Lutfi Kirdar Kartal Training and Research Hospital October 30 2023 --

Chemical lnformation & Solubility

Molecular Weight 234.34 Formula

C14H22N2O
CAS No. 137-58-6 SDF Download Lidocaine SDF
Smiles CCN(CC)CC(=O)NC1=C(C=CC=C1C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 47 mg/mL ( (200.56 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 47 mg/mL

Water : 9 mg/mL


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In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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