Home Metabolism PDE inhibitor Milrinone For research use only.

Milrinone

Synonyms: Win 47203,Primacor

Milrinone (Win 47203,Primacor) is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.

Milrinone Chemical Structure

Milrinone Chemical Structure

CAS: 78415-72-2

Selleck's Milrinone has been cited by 3 Publications

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Purity & Quality Control

Batch: Purity: 99.99%
99.99

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Biological Activity

Description Milrinone (Win 47203,Primacor) is a phosphodiesterase 3 (PDE3) inhibitor, used to increase the heart's contractility.
Targets
ATPase [1] PDE3 [7] PDE2 [7]
2.1 μM 5.2 μM
In vitro
In vitro

Milrinone causes a concentration-dependent increase in the cAMP level in rabbit and human platelets with similar potency. Milrinone inhibits human platelet aggregation with a median inhibitory concentration (IC50) of 2 mM.Milrinone concentration-dependently increases left ventricular developed pressure (LVDP) and contractility. Milrinone concentration-dependently increases cAMP in rabbit coronary smooth muscle cells. [1] Milrinone increases intracellular cyclic adenosine monophosphate by inhibiting Type III phosphodiesterase. [2] Milrinone is a potent (IC50 = 0.16-0.90 mM) and selective (100 times peak III relative to peak I) peak III inhibitor. Milrinone significant increases in cAMP content accompany significant vasorelaxation. [3]
In Vivo
In vivo

Milrinone inhibits PDE4 in addition to PDE3 activity in the rabbit heart.Milrinone (>10 microM) causes greater elevations in intracellular cAMP and calcium than cilostazol. [4] Milrinone causes similar increases in heart rate, cardiac output, and left ventricular +dP/dt and decreases in end-diastolic pressure and systemic vascular resistance in anaesthetized dogs. [5] Milrinone leads to significant increases in right ventricular function as well as significant improvements in pulmonary vascular resistance, pulmonary blood flow, and left ventricular filling in mongrel dogs underwent pulmonary artery catheterization. [6]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06032195 Active not recruiting Heart Transplantation Dr. F. Köhler Chemie GmbH August 15 2023 Phase 2
NCT05830136 Recruiting Hepatic Ischemia The First Affiliated Hospital with Nanjing Medical University February 1 2022 Not Applicable
NCT05132153 Recruiting Anesthesia Ain Shams University October 17 2021 Phase 4
NCT03945708 Completed Infective Endocarditis Emma Hansson|CytoSorbents Inc|Sahlgrenska University Hospital Sweden May 15 2019 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 211.22 Formula

  C12H9N3O
CAS No. 78415-72-2 SDF Download Milrinone SDF
Smiles CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 42 mg/mL ( (198.84 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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