Home Metabolism Antineoplastic and Immunosuppressive Antibiotics inhibitor - Dehydrogenase inhibitor - Selection Antibiotics for Transfected Cell chemical Mycophenolic acid For research use only.

Mycophenolic acid

Synonyms: Mycophenolate, RS-61443

Mycophenolic acid (Mycophenolate, RS-61443) is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.

Mycophenolic acid Chemical Structure

Mycophenolic acid Chemical Structure

CAS: 24280-93-1

Selleck's Mycophenolic acid has been cited by 10 publications

Purity & Quality Control

Batch: Purity: 99.95%
99.95

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Biological Activity

Description Mycophenolic acid (Mycophenolate, RS-61443) is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation.
Targets
IMPDH [1]
In vitro
In vitro Mycophenolic acid inhibits inosine-5'-monophosphate dehydrogenase (IMPDH) by acting as a replacement for the nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule. [1] Mycophenolic acid (MPA), an inhibitor of inosine monophosphate dehydrogenase, in nanomolar concentrations blocks proliferative responses of cultured human, mouse and rat T lymphocytes and B lymphocytes to mitogens or in mixed lymphocyte reactions. Mycophenolic acid (MPA) suppresses mixed lymphocyte reactions when added 3 days after their initiation. Mycophenolic acid also inhibits antibody formation by polyclonally activated human B lymphocytes. Mycophenolic acid is an immunosuppressive agent reversibly inhibiting proliferation of T and B lymphocytes and antibody formation, with a profile of activity different from that of other immunosuppressive drugs. [2] Mycophenolic acid inhibits the formation of antibodies to sheep erythrocytes. Mycophenolic acid also suppresses, in a dose-related manner, the generation of cytotoxic T-lymphocytes against allogeneic cells in mice and prevents the elimination of allogeneic cells. [3] Mycophenolic acid induces apoptosis and cell death in a large proportion of activated CD4+ T cells. [4]
In Vivo
In vivo Mycophenolic acid has lymphocyte-selective anti-proliferative effects in mice and can inhibit both cell-mediated and humoral immune responses without major side effects. [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06001320 Recruiting Kidney Transplant; Complications|CMV Virginia Commonwealth University|Merck Sharp & Dohme LLC September 25 2023 Early Phase 1
NCT05859191 Recruiting Systemic Lupus Erythematosus|Physiopathology University Hospital Tours|Research Center for Respiratory Diseases Inserm U1100 July 21 2023 --
NCT05702931 Not yet recruiting Hyperglycemia|Renal Transplant Complication Primary Non-Function|Diabetes Rigshospitalet Denmark|Aarhus University Hospital Department of Nephrology|Odense University Hospital Department of Nephrology April 1 2023 Phase 4
NCT05005221 Recruiting Kidney Transplant University of Michigan November 8 2022 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 320.34 Formula

C17H20O6
CAS No. 24280-93-1 SDF Download Mycophenolic acid SDF
Smiles CC1=C2COC(=O)C2=C(C(=C1OC)CC=C(C)CCC(=O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 64 mg/mL ( (199.78 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 32 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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