Home Transmembrane Transporters Calcium Channel inhibitor Nifedipine For research use only.

Nifedipine

Synonyms: BAY-a-1040

Nifedipine is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.

Nifedipine Chemical Structure

Nifedipine Chemical Structure

CAS: 21829-25-4

Selleck's Nifedipine has been cited by 12 Publications

2 Customer Reviews

Purity & Quality Control

Batch: Purity: 99.69%
99.69

Other Calcium Channel Products

Related compound libraries

Choose Selective Calcium Channel Inhibitors

Biological Activity

Description Nifedipine is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.
Targets
calcium channel [1]
In vitro
In vitro Nifedipine causes a significant concentration-dependent increase in eNOS protein expression by cultured human coronary artery endothelial cells. [1] Nifedipine antagonizes L-type Ca+ channels found throughout the cardiovascular system, but also blocks Kv channels, which are members of the same supergene family. [2] Nifedipine dose-dependently decreases the values of [(3)H]-thymidine incorporation and total cellular protein content as well as the levels of phosphorylated extracellular signal-regulated protein kinase (ERK) 1/2, mitogen-activated protein kinase kinase (MEK) 1/2, and even the phosphorylation of Pyk2, in vascular smooth muscle cells (VSMC). Nifedipine suppresses the levels of proliferative cell nuclear antigen (PCNA) dose-dependently in both VSMC and balloon-injured thoracic aortae in VSMC. [3]
In Vivo
In vivo Nifedipine (3 mg/kg) slightly lowers the level of systolic and/or diastolic blood pressure or increased the heart rate in rats. [3] Nifedipine (1 μm) produces a maximal inhibition of the store-operated pathway in choroidal arteriolar smooth muscle. [4] Nifedipine (20 and 40 mg/kg) markedly prevents the HCl plus ethanol-induced gastric mucosal injury and the increase in the content of thiobarbituric acid-reactive substances in the injured mucosa in rats. Nifedipine (20 and 40 mg/kg) dose-dependently promotes the ulcer healing and inhibites the increase in the content of thiobarbituric acid-reactive substances in the ulcerated mucosa in rats. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05096728 Completed Preeclampsia With Severe Features Ohio State University December 1 2021 --
NCT04392375 Completed Preeclampsia Severe Ohio State University June 9 2020 Phase 4
NCT03695107 Unknown status Chronic Kidney Diseases The Third Xiangya Hospital of Central South University October 2 2019 --
NCT02902354 Withdrawn Tocolysis With Nifedipine St. Louis University September 2016 Not Applicable
NCT03710395 Unknown status Drug Transporter Natalia Valadares de Moraes|Hospital das Clínicas de Ribeirão Preto|Universidade Estadual Paulista Júlio de Mesquita Filho December 14 2015 Phase 4

Chemical lnformation & Solubility

Molecular Weight 346.33 Formula

C17H18N2O6
CAS No. 21829-25-4 SDF Download Nifedipine SDF
Smiles CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
Storage (From the date of receipt) 2 years 4°C(in the dark) powder

In vitro
Batch:

DMSO : 69 mg/mL ( (199.23 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 15 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Nifedipine | Nifedipine supplier | purchase Nifedipine | Nifedipine cost | Nifedipine manufacturer | order Nifedipine | Nifedipine distributor