Home Transmembrane Transporters Calcium Channel inhibitor - Autophagy activator Nimodipine For research use only.

Nimodipine

Synonyms: BAY E 9736

Nimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.

Nimodipine Chemical Structure

Nimodipine Chemical Structure

CAS: 66085-59-4

Selleck's Nimodipine has been cited by 3 Publications

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Purity & Quality Control

Batch: Purity: 100%
100

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Biological Activity

Description Nimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.
Targets
Calcium channel [1]
In vitro
In vitro Nimodipine decreases both the peak amplitude and the integrated area of the AHP in an age- and concentration-dependent manner. Nimodipine (100 nM) significantly reduces the AHP in aging CA1 neurons. Nimodipine increases excitability in an age- and concentration-dependent manner by decreasing spike frequency accommodation (increasing the number of action potentials during prolonged depolarizing current injection). Nimodipine decreases accommodation only at higher concentrations in young CA1 neurons. [1] Nimodipine decreases the plateau phase of the calcium AP at concentrations as low as 100 nM in aging neurons and 10 mM in young rat neurons. [2]
In Vivo
In vivo Nimodipine results in reversible, dose-related suppression of the compound action potential of the auditory nerve (CAP; N1-P1), a prolongation of N1 latency at suprathreshold levels, an elevated CAP threshold, a decrease in N1 latency at a constant amplitude measured at CAP threshold, a reduction in cochlear microphonics (CM), and a reduction of the negative summating potential (SP) to a point where it becomes positive. [3] Nimodipine (10 mg/kg, SC), an L-type dihydropyridine Ca2+ channel antagonist, appears to completely block the establishment of conditioning of cocaine's effects, but only partially blocks sensitization to cocaine. [4] Nimodipine (5-20 mg/kg, SC) inhibits in a dose-related manner self-administration both of cocaine and morphine contingent upon a nose-poke response. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05995405 Recruiting Aneurysmal Subarachnoid Hemorrhage (aSAH) Acasti Pharma Inc. October 20 2023 Phase 3
NCT04998370 Recruiting Subarachnoid Hemorrhage Aneurysmal|Vasospasm|Delayed Cerebral Ischemia|Delayed Ischemic Neurological Deficit University of Zurich August 18 2021 --
NCT04649398 Recruiting Subarachnoid Hemorrhage Aneurysmal|Delayed Cerebral Ischemia|Vasospasm Cerebral Medical University of Vienna|University of Vienna|Austrian Science Fund (FWF) November 25 2020 --
NCT02991157 Completed Subarachnoid Hemorrhage Aneurysmal National Institute of Mental Health and Neuro Sciences India December 2016 --
NCT01835665 Completed Progranulin Mutation Carriers University of California San Francisco|The Bluefield Project to Cure Frontotemporal Dementia March 2013 Phase 1
NCT01551368 Terminated Infertility Mount Sinai Hospital Canada December 2012 Phase 2

Chemical lnformation & Solubility

Molecular Weight 418.44 Formula

C21H26N2O7
CAS No. 66085-59-4 SDF Download Nimodipine SDF
Smiles CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 84 mg/mL ( (200.74 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 84 mg/mL

Water : Insoluble


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In vivo
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