Home Transmembrane Transporters Sodium Channel inhibitor Oxcarbazepine For research use only.

Oxcarbazepine

Synonyms: GP47680

Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.

Oxcarbazepine Chemical Structure

Oxcarbazepine Chemical Structure

CAS: 28721-07-5

Purity & Quality Control

Batch: S139101 DMSO] 7 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.95%
99.95

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Biological Activity

Description Oxcarbazepine (GP47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.
Targets
sodium channel [1]
160 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02104661 Completed Multiple Sclerosis Queen Mary University of London|National Multiple Sclerosis Society|Novartis Pharmaceuticals|Barts & The London NHS Trust|University College London|Royal Free Hospital NHS Foundation Trust|Mid and South Essex NHS Foundation Trust|St George''s Healthcare NHS Trust|Barnet and Chase Farm Hospitals NHS Trust October 2014 Phase 2
NCT02098941 Unknown status Epilepsy Seoul National University Hospital|Janssen Korea Ltd. Korea March 2014 --
NCT02362373 Completed Epilepsy|Contraception Columbia University|Bayer August 2011 Phase 4
NCT00951847 Completed Healthy Ranbaxy Laboratories Limited|Ranbaxy Inc. October 2006 Not Applicable
NCT00951600 Completed Healthy Ranbaxy Laboratories Limited|Ranbaxy Inc. September 2006 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 252.27 Formula

C15H12N2O2
CAS No. 28721-07-5 SDF Download Oxcarbazepine SDF
Smiles C1C2=CC=CC=C2N(C3=CC=CC=C3C1=O)C(=O)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 7 mg/mL ( (27.74 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

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