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Prednisolone

Name: Prednisolone
Brand: Selleck Chemicals
SKU: S1737
Rating: 5 (14 reviews)

Synonyms: NSC-9900

Catalog No.S1737 Purity: 99.97%

Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

Prednisolone Chemical Structure

CAS: 50-24-8

Selleck's Prednisolone has been cited by 14 Publications

2 Customer Reviews

Purity & Quality Control

Batch: Purity: 99.97%

99.97

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Choose Selective Glucocorticoid Receptor Inhibitors

Biological Activity

Description

Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

Targets

Glucocorticoid receptor ^[1]

In vitro
In vitro	Prednisolone (50 mg/kg, im) given 15 min before LPS-attenuated production of NO2- and NO3- by neutrophils and suppresses LPS-stimulated mRNA for NOS II in rat neutrophils. ^[1] Prednisolone reduces joint swelling through a mechanism associated with a reduction in IL-1beta and IL-6 protein and mRNA expression levels in SCW-induced arthritis rats. ^[2] Prednisolone's anti-inflammatory effects can be mediated by reducing cellular adhesion molecule (CAM) expression. Prednisolone (0.75 mg/kg) reduces macrophages (-59%, -57%), CD4(+) T-cells (-50%, -60%), CD8(+) T-cells (-58%, -48%), and eosinophils (-36%, -25%) in quadriceps and soleus muscles, respectively. Prednisolone-treated mice also exhibits decreased vascular P-selectin (-82%) and ICAM-1 (-52%) expression and fewer L-selectin (-79%) and ICAM-1 (-57%) expressing mononuclear cells in quadriceps. Prednisolone reduces sarcolemmal damage and degeneration as well in Dystrophin-deficient, mdx mice. ^[3]

In Vivo
In vivo	Prednisolone (5 mg/kg) causes alterations in diaphragmatic contractile properties and histological changes without fiber atrophy in rats. Prednisolone results in an increased number of diaphragmatic bundles in rats. ^[4] Prednisolone induces a significant decline of PL-pO2, while CoBF, CMs, CAPs, and ABRs revealed no change in guinea pigs. ^[5]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06119529	Not yet recruiting	Healthy\|Atopic Dermatitis	Eli Lilly and Company	November 1 2023	Phase 1
NCT05986422	Recruiting	Post-COVID-19 Syndrome	Charite University Berlin Germany	October 1 2023	Phase 2
NCT06066814	Not yet recruiting	Acute on Chronic Liver Failure	Institute of Liver and Biliary Sciences India	October 7 2023	--
NCT05984381	Recruiting	Bullous Pemphigoid	All India Institute of Medical Sciences Bhubaneswar	August 1 2023	Phase 4

References

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Chemical lnformation & Solubility

Molecular Weight	360.44	Formula	C₂₁H₂₈O₅
CAS No.	50-24-8	SDF	Download Prednisolone SDF
Smiles	CC12CC(C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 72 mg/mL ( (199.75 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 40 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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