Home DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor Vidarabine For research use only.

Vidarabine

Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.

Vidarabine Chemical Structure

Vidarabine Chemical Structure

CAS: 5536-17-4

Selleck's Vidarabine has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 100%
100

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Biological Activity

Description Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.
Targets
DNA polymerase [1]
In vitro
In vitro Vidarabine and Acyclovir have a synergistic effect on wild type . Vidarabine is capable of inhibiting acyclovir-resistant/TK-deficient mutants of HSV and VZV, because it is phosphorylated to its active vidarabine–triphosphate form by cellular kinases and is not dependent for its activation on the viral TK. [1] Vidarabine and acyclovir (ACV) alone show a concentration-dependent inhibition of plaque formation of HSV-1 in Vero cells. Vidarabine combined with acidic protein bound polysaccharide (APBP) show synergistic effects on the plaque formation of HSV-1 in Vero cells. [2] Vidarabine acts directly on the DNA polymerase of varicella-zoster virus (VZV) and double-strand DNA viruses, including human adenoviruses. Vidarabine specifically inhibits adenovirus type 11 replication without obvious cytotoxicity in vitro. Vidarabine acts less on the synthesis of early proteins but rather on those after DNA replication. [3] Vidarabine is an antiviral drug with activity against herpes viruses, poxviruses, and certain rhabdoviruses, hepadnarviruses, and RNA tumor viruses. Vidarabine also is active against vaccinia virus both in vitro and in vivo. [4]
In Vivo
In vivo Vidarabine is rapidly deaminated to 9-β-D-arabinofuranosyl hypoxanthine (Ara-Hx) as the principal metabolite. [3]

Chemical lnformation & Solubility

Molecular Weight 267.24 Formula

C10H13N5O4
CAS No. 5536-17-4 SDF Download Vidarabine SDF
Smiles C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)CO)O)O)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 53 mg/mL ( (198.32 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 3 mg/mL

Ethanol : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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