Home DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor Amenamevir For research use only.

Amenamevir

Synonyms: ASP2151

Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.

Amenamevir Chemical Structure

Amenamevir Chemical Structure

CAS: 841301-32-4

Selleck's Amenamevir has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.95%
99.95

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Biological Activity

Description Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.
Targets
helicase-primase [1]
In vitro
In vitro ASP2151 inhibited the in vitro replication of HSV-1. The mean EC50s of ASP2151 against HSV-1 and HSV-2 were 14 (range, 7.7 to 20) and 30 ng/ml (range, 15 to 58), respectively[2].
In Vivo
In vivo In the cutaneously HSV-1-infected mouse model, ASP2151 dose dependently suppressed intradermal HSV-1 growth, with the effect reaching a plateau at a dose of 30 mg/kg of body weight/day[2].
Animal Research Animal Models HSV-1-infected mice
Dosages 1, 3, 10, 30, or 100 mg/kg/day
Administration oral
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02223351 Completed Healthy Maruho Europe Limited September 2014 Phase 1
NCT00487682 Completed Herpes Zoster Astellas Pharma Inc November 13 2007 Phase 2
NCT00486200 Completed Herpes Genitalis Astellas Pharma Inc June 21 2007 Phase 2
NCT02796118 Completed Healthy Subjects Astellas Pharma Inc July 2006 Phase 1
NCT02852876 Completed Herpes Genitalis|Herpes Zoster Astellas Pharma Europe Ltd.|Astellas Pharma Inc September 2005 Phase 1

Chemical lnformation & Solubility

Molecular Weight 482.55 Formula

C24H26N4O5S
CAS No. 841301-32-4 SDF --
Smiles CC1=C(C(=CC=C1)C)N(CC(=O)NC2=CC=C(C=C2)C3=NOC=N3)C(=O)C4CCS(=O)(=O)CC4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:


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In vivo
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Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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