Home Transmembrane Transporters Sodium Channel inhibitor Zonisamide For research use only.

Zonisamide

Synonyms: Zonegran,CI-912,AD 810

Zonisamide (Zonegran,CI-912,AD 810) is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.

Zonisamide Chemical Structure

Zonisamide Chemical Structure

CAS: 68291-97-4

Selleck's Zonisamide has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.98%
99.98

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Biological Activity

Description Zonisamide (Zonegran,CI-912,AD 810) is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.
Targets
Sodium channel [1]
In vitro
In vitro

Zonisamide inhibits monoamine oxidase B (MAO-B) activity in vitro with an IC(50) of 25 μM. [1]
In Vivo
In vivo

Zonisamide modifies dopamine (DA) activity, provides protection in ischemia mice models and influences antioxidant systems. Zonisamide attenuates the reduction in striatal contents of DA, its metabolite DOPAC and tyrosine hydroxylase (TH). [1] Zonisamide (10 and 30 mg/kg) produces antihyperalgesic and antiallodynic effects in a dose-dependent manner, these effects are manifested by elevation of the withdrawal threshold in response to a thermal (plantar test) or mechanical (von Frey) stimulus, respectively.. Zonisamide produces antinociceptive effects against acute thermal and mechanical nociception in non-ligated mice. [2] Zonisamide reduces the cortical infarction volume to 6% from 68% in vehicle-treated controls and the striatal volume to 8% from 78% in rats. Zonisamide also reduces neuronal necrosis in 5 hippocampal regions (the dentate gyrus, CA4, CA3, CA1, and the subiculum) in rats. [3] Zonisamide causes increase in the quantity of EAAC-1 protein in hippocampus and cortex and down regulation of the GABA transporter GAT-1 in rats with hippocampal seizures. [4] Zonisamide inhibits both the 50 mM KCl-evoked hippocampal glutamate release (AUC for 60 min) from 9.2 mM to 5.8 mM in urethane-anaesthetized rats, as well as the stimulatory effects of Ca2+ on KCl-evoked hippocampal glutamate release. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04774250 Terminated Hearing Loss Noise-Induced Washington University School of Medicine|United States Department of Defense|University of Texas|Gateway Biotechnology Inc. November 10 2021 Phase 2
NCT01830868 Completed Partial Onset Seizures Eisai Inc. March 2012 --
NCT01283256 Completed Partial Generalized and Combined Seizures Eisai Inc. January 2011 --
NCT01765608 Completed Sleep Apnea|Obstructive Sleep Apnea|Obesity Göteborg University|Eisai Inc. March 2010 Phase 2
NCT00203450 Completed Obesity Tuscaloosa Research & Education Advancement Corporation|Eisai Inc. May 2003 Phase 4

Chemical lnformation & Solubility

Molecular Weight 212.23 Formula

C8H8N2O3S
CAS No. 68291-97-4 SDF Download Zonisamide SDF
Smiles C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 42 mg/mL ( (197.89 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 11 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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