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Nab-Paclitaxel

Name: Nab-Paclitaxel
Brand: Selleck Chemicals
SKU: E1068
Rating: 5 (1 reviews)

Catalog No.E1068 Purity: 99.18%

Nab-Paclitaxel, a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system.

Nab-Paclitaxel Chemical Structure

CAS:

Selleck's Nab-Paclitaxel has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.18%

99.18

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Biological Activity

Description	Nab-Paclitaxel, a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system.

In vitro
In vitro	Treating human pancreatic ductal adenocarcinoma cells first with gemcitabine followed by Nab-Paclitaxel at 48 hours is found to have the greatest inhibition of cell growth.^[3]
Cell Research	Cell lines	Human pancreatic ductal adenocarcinoma cell lines
	Concentrations	100 nM
	Incubation Time	24 h
	Method	Cells are seeded in 96-well plates at a density of 1,000–5,000 cells per well in 100 μL medium. Nab-Paclitaxel and gemcitabine are added and incubated at 37°C for 24 hours. Proliferation Is measured by the alamarBlue assay.

In Vivo
In vivo	In mice with human pancreatic cancer xenografts, nab-paclitaxel alone and in combination with gemcitabine deplete the desmoplastic stroma. The intratumoral concentration of gemcitabine is increased by 2.8-fold in mice receiving nab-paclitaxel plus gemcitabine versus those receiving gemcitabine alone.^[4]

References

[4] Von Hoff DD, et al. J Clin Oncol. 2011 Dec 1;29(34):4548-54.

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Chemical lnformation & Solubility

Molecular Weight	853.91（Only for Paclitaxel）	Formula	C47H51NO14
CAS No.		SDF	--
Storage (From the date of receipt)	Store at room temperature, 3 years	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	Store at room temperature, 3 years		1 month-20°Cin solvent

In vitro
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In vivo
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