Home Protein Tyrosine Kinase ALK inhibitor - FAK inhibitor - Serine/threonin kinase inhibitor ALK inhibitor 1 For research use only.

ALK inhibitor 1

Synonyms: compound 17

ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor which can inhibit testis-specific serine/threonine kinase (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM).

ALK inhibitor 1 Chemical Structure

ALK inhibitor 1 Chemical Structure

CAS: 761436-81-1

Purity & Quality Control

Batch: E283601 DMSO] 100 mg/mL] false] Water] 25 mg/mL] false] Ethanol] 2 mg/mL] false Purity: 99.68%
99.68

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Biological Activity

Description ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor which can inhibit testis-specific serine/threonine kinase (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM).
Targets
ALK [1] FAK [1]
(in a robust mobility shift assay)		 TSSK2 [1]
(in a robust mobility shift assay)
2 nM 31 nM

Chemical lnformation & Solubility

Molecular Weight 562.48 Formula

C23H28BrN7O3S
CAS No. 761436-81-1 SDF --
Smiles CN[S](=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Br)NC3=CC=C(C=C3OC)N4CCN(C)CC4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (177.78 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 25 mg/mL

Ethanol : 2 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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