Home Transmembrane Transporters Sodium Channel inhibitor Ambroxol HCl For research use only.

Ambroxol HCl

AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.

Ambroxol HCl Chemical Structure

Ambroxol HCl Chemical Structure

CAS: 23828-92-4

Purity & Quality Control

Batch: Purity: 99.91%
99.91

Other Sodium Channel Products

Related compound libraries

Choose Selective Sodium Channel Inhibitors

Biological Activity

Description AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.
Targets
Sodium channel [1]
35.2 μM-22.5 μM
In vitro
In vitro Ambroxol inhibits Na+ channels in sensory neurons. The potency for tonic block of TTX-r channels is relatively high. Ambroxol affects the Na+ current kinetics of TTX-r and TTX-s channels differently. In CNaIIA cells, the compound behaves like a charged local anesthetic: the block is dependent on stimulus number and increases with higher frequencies in a train of depolarizing stimuli. In CNaIIA cells, ambroxol inhibits inactivated channels 5.5-fold more potently than resting channels. The corresponding factor for TTX-r channels is only 3.3.[1] Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. [2]
In Vivo
In vivo Ambroxol inhibited histamine release by more than 50% from human adenoidal mast cells (1000 microM ambroxol) and skin mast cells (100 microM ambroxol) stimulated by Con A and compound 48/80, respectively. Ambroxol (100 microM) strikingly inhibited anti-IgE induced release of both histamine, LTC4, IL-4 and IL-13 from basophils and reduced both histamine and LTB4 release induced by C5a or Zymosan in monocytes. The drug also reduced LTB4 and superoxide anion production in granulocytes stimulated by zymosan or fMLP.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04405596 Not yet recruiting Lewy Body Disease Lawson Health Research Institute January 2025 Phase 1|Phase 2
NCT05778617 Not yet recruiting Parkinson Disease University College London September 2023 Phase 3
NCT05558878 Not yet recruiting Diabetic Neuropathy Peripheral Ain Shams University October 1 2022 Not Applicable
NCT05287503 Active not recruiting Parkinson Disease|GBA Gene Mutation Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta|IRCCS National Neurological Institute C. Mondino Foundation|University of Campania Luigi Vanvitelli February 15 2022 Phase 2
NCT04388969 Recruiting Gaucher Disease|Parkinson Disease|GBA Gene Mutation Shaare Zedek Medical Center May 6 2020 --

Chemical lnformation & Solubility

Molecular Weight 414.56 Formula

C13H18Br2N2O.HCl
CAS No. 23828-92-4 SDF Download Ambroxol HCl SDF
Smiles C1CC(CCC1NCC2=C(C(=CC(=C2)Br)Br)N)O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 6 mg/mL ( (14.47 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Ambroxol HCl | Ambroxol HCl supplier | purchase Ambroxol HCl | Ambroxol HCl cost | Ambroxol HCl manufacturer | order Ambroxol HCl | Ambroxol HCl distributor