Home Transmembrane Transporters Sodium Channel inhibitor Ambroxol For research use only.

Ambroxol

Ambroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels.

Ambroxol Chemical Structure

Ambroxol Chemical Structure

CAS: 18683-91-5

Purity & Quality Control

Batch: S571001 DMSO] 76 mg/mL] false] ] ] false] ] ] false Purity: 99.9%
99.9

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Biological Activity

Description Ambroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04405596 Not yet recruiting Lewy Body Disease Lawson Health Research Institute January 2025 Phase 1|Phase 2
NCT05778617 Not yet recruiting Parkinson Disease University College London September 2023 Phase 3
NCT05558878 Not yet recruiting Diabetic Neuropathy Peripheral Ain Shams University October 1 2022 Not Applicable
NCT05287503 Active not recruiting Parkinson Disease|GBA Gene Mutation Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta|IRCCS National Neurological Institute C. Mondino Foundation|University of Campania Luigi Vanvitelli February 15 2022 Phase 2
NCT04388969 Recruiting Gaucher Disease|Parkinson Disease|GBA Gene Mutation Shaare Zedek Medical Center May 6 2020 --

Chemical lnformation & Solubility

Molecular Weight 378.10 Formula

C13H18Br2N2O
CAS No. 18683-91-5 SDF --
Smiles C1CC(CCC1NCC2=C(C(=CC(=C2)Br)Br)N)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 76 mg/mL ( (201.0 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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