Home Transmembrane Transporters Potassium Channel inhibitor 4-Aminopyridine For research use only.

4-Aminopyridine

Synonyms: Fampridine, Dalfampridine

4-Aminopyridine (4-AP, Fampridine, Dalfampridine) is a potent and non-selective inhibitor of voltage gated potassium channels (Kv) with IC50 values of 170 μM and 230 μM for Kv1.1 and Kv1.2 in CHO cells, respectively.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.

4-Aminopyridine Chemical Structure

4-Aminopyridine Chemical Structure

CAS: 504-24-5

Purity & Quality Control

Batch: S502801 DMSO] 18 mg/mL] false] ] ] false] ] ] false Purity: 99.99%
99.99

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Biological Activity

Description 4-Aminopyridine (4-AP, Fampridine, Dalfampridine) is a potent and non-selective inhibitor of voltage gated potassium channels (Kv) with IC50 values of 170 μM and 230 μM for Kv1.1 and Kv1.2 in CHO cells, respectively.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Targets
Kv1.4 [2] Kv3.1 [2] Kv3.2 [2] Kv1.3 [2] Kv1.1 [2] Click to View More Targets
13 μM 29 μM 100 μM 195 μM 290 μM
In vitro
In vitro Working from the intracellular side of the channel, 4-AP inhibits a wide variety of voltage-dependent K+ channels with affinities ranging from the mid-micromolar to the millimolar range[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05338450 Recruiting Multiple Sclerosis|Internuclear Ophthalmoplegia Amsterdam UMC location VUmc August 30 2022 Phase 3
NCT02868567 Active not recruiting Motor Neuron Disease Upper Hospital for Special Surgery New York March 2016 Phase 1
NCT02422940 Terminated Post-ischemic Stroke Acorda Therapeutics April 2015 Phase 3
NCT02208882 Completed Healthy Adult Volunteers Bristol-Myers Squibb August 2014 Phase 1
NCT02208050 Completed Secondary Progressive Multiple Sclerosis|Primary Progressive Multiple Sclerosis University College Dublin February 21 2014 Phase 4

Chemical lnformation & Solubility

Molecular Weight 94.11 Formula

C5H6N2
CAS No. 504-24-5 SDF --
Smiles C1=CN=CC=C1N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 18 mg/mL ( (191.26 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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