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Articaine HCl

Name: Articaine HCl
Brand: Selleck Chemicals
SKU: S3150

Synonyms: Ultracaine

Catalog No.S3150 Purity: 99.70%

Articaine (Ultracaine) is a dental local anesthetic which contains an additional ester group that is metabolized by estearases in blood and tissue.

Articaine HCl Chemical Structure

CAS: 23964-57-0

Purity & Quality Control

Batch: S315001 DMSO] 64 mg/mL] false] Water] 64 mg/mL] false] Ethanol] 64 mg/mL] false Purity: 99.70%

99.70

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Biological Activity

Description	Articaine (Ultracaine) is a dental local anesthetic which contains an additional ester group that is metabolized by estearases in blood and tissue.

In Vivo
In vivo	The time to maximum drug concentrations of articaine occurs about 10 to 15 minutes after submucosal injection of articaine 4% 80 mg. The elimination half-time of articaine is about 20 minutes. Articaine is better able to diffuse through soft tissue and bone than other local anaesthetics, the concentration of articaine in the alveolus of a tooth in the upper jaw after extraction is about 100 times higher than that in systemic circulation. ^[1] Articaine: VAS (Visual Analogue Scale) scores (from 0 to 10 cm) by patients 4 to < 13 years of age are 0.5 for simple procedures and 1.1 for complex procedures, and average investigator scores are 0.4 and 0.6 for simple and complex procedures, respectively. No serious adverse events related to the articaine occurres, the only adverse event considered related to articaine is accidental lip injury in one patient. ^[2] Articaine results in success rate of 64.5% in electronic pulp testing in healthy adult volunteers injected with 4% articaine. Articaine infiltration produces significantly more episodes of no response to maximum stimulation in first molars than lidocaine. Mandibular buccal infiltration is more effective with 4% articaine with epinephrine compared to 2% lidocaine with epinephrine. ^[3] Articaine (4%) results in the success rate of 24% for the inferior alveolar nerve block in randomized, double-blind study. ^[4] Articaine formulation results in successful pulpal anesthesia ranged from 75 to 92 percent and onset of pulpal anesthesia ranged from 4.2 to 4.7 minutes in healthy volunteer. For articaine, 4 percent (two of 56) of the subjects reported swelling and no subjects reported bruising. Ninety-eight percent (59 of 60) of the subjects had lip numbness with the articaine solution. ^[5]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT04759339	Completed	Healthy	American Genomics LLC	February 24 2021	Phase 1
NCT03174860	Completed	Pulpitis - Irreversible\|Anesthesia Local	Cairo University	October 2016	Phase 2\|Phase 3
NCT01496846	Completed	Irreversible Pulpitis	University of Michigan\|Dentsply International	September 2011	Phase 4

References

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Chemical lnformation & Solubility

Molecular Weight	320.84	Formula	C₁₃H₂₀N₂O₃S.HCl
CAS No.	23964-57-0	SDF	Download Articaine HCl SDF
Smiles	CCCNC(C)C(=O)NC1=C(SC=C1C)C(=O)OC.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 64 mg/mL ( (199.47 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 64 mg/mL

Ethanol : 64 mg/mL

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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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